Component
Human transcription factor EB / TFEB
Context-specific entity; species, compartment and exposure are stated on each claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Autophagy and lysosomal biogenesis through TFEB required MCOLN1-mediated calcineurin activation.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Cellular starvation and mouse exercise experiments.
- limitations
- Lysosome abundance alone is not proof of increased degradation flux.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- The signal helped build the cell’s recycling capacity.
- primary_references
- Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25720963/ · DOI 10.1038/ncb3114
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 344–350
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Cellular starvation and mouse exercise experiments. · source_derived_draft · unverified_draft
## fast-tfeb-biogenesis The signal helped build the cell’s recycling capacity. Autophagy and lysosomal biogenesis through TFEB required MCOLN1-mediated calcineurin activation. Model: Cellular starvation and mouse exercise experiments. Limitations: Lysosome abundance alone is not proof of increased degradation flux. Evidence access: Primary abstract Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25720963/ · DOI 10.1038/ncb3114
Complete structured claim and evidence
What acts on it
Spermidine restored TFEB protein and eIF5A hypusination in older-donor CD8 cells and in DFMO-treated young-donor cells.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Primary human T-cell cultures.
- limitations
- Total eIF5A and its modified fraction are different measurements.
- nutrient_topic
- Spermidine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Spermidine
- plain_language
- A measured protein response links the pathway to autophagy.
- primary_references
- Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33317695/ · DOI 10.7554/eLife.57950
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Spermidine: biosynthesis, hypusination, transport and cross-nutrient mechanisms (2026-09-19) · lines 246–252
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Primary human T-cell cultures. · source_derived_draft · unverified_draft
## spermidine-tcell-tfeb A measured protein response links the pathway to autophagy. Spermidine restored TFEB protein and eIF5A hypusination in older-donor CD8 cells and in DFMO-treated young-donor cells. Model: Primary human T-cell cultures. Limitations: Total eIF5A and its modified fraction are different measurements. Evidence access: Primary full text Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33317695/ · DOI 10.7554/eLife.57950
Complete structured claim and evidenceCalcineurin bound and dephosphorylated TFEB, promoting its nuclear translocation.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Genetic and pharmacological perturbation of the calcineurin–TFEB pathway.
- limitations
- This establishes a regulatory route, not a fixed fasting schedule.
- nutrient_topic
- Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
- plain_language
- Removing phosphate marks let a regulator reach the nucleus.
- primary_references
- Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25720963/ · DOI 10.1038/ncb3114
Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 336–342
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Genetic and pharmacological perturbation of the calcineurin–TFEB pathway. · source_derived_draft · unverified_draft
## fast-tfeb-dephosphorylation Removing phosphate marks let a regulator reach the nucleus. Calcineurin bound and dephosphorylated TFEB, promoting its nuclear translocation. Model: Genetic and pharmacological perturbation of the calcineurin–TFEB pathway. Limitations: This establishes a regulatory route, not a fixed fasting schedule. Evidence access: Primary abstract Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25720963/ · DOI 10.1038/ncb3114
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.