{"id":"0bcf3a11-58f3-5add-a622-4e5bacbc61f8","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-tfeb-dephosphorylation","predicate":"dephosphorylates","statement":"Calcineurin bound and dephosphorylated TFEB, promoting its nuclear translocation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a50c6ea0-7124-517b-b957-291a8bf9ef01","mechanism_event_label":"Removing phosphate marks let a regulator reach the nucleus.","subject":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"object":{"id":"a04514ba-11bb-5809-8d2f-75ca964fad15","slug":"tfeb","display_name":"Human transcription factor EB / TFEB","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"a50c6ea0-7124-517b-b957-291a8bf9ef01","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-tfeb-dephosphorylation-event","event_type":"observed_relationship","label":"Removing phosphate marks let a regulator reach the nucleus.","description":"Calcineurin bound and dephosphorylated TFEB, promoting its nuclear translocation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a04514ba-11bb-5809-8d2f-75ca964fad15","slug":"tfeb","display_name":"Human transcription factor EB / TFEB","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a1dfeac9-9811-5963-8bd1-753a211be5f4","slug":"tfeb-nuclear-translocation","display_name":"TFEB nuclear translocation","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Genetic and pharmacological perturbation of the calcineurin–TFEB pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This establishes a regulatory route, not a fixed fasting schedule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Removing phosphate marks let a regulator reach the nucleus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25720963/ · DOI 10.1038/ncb3114","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6a8c6fd7-852a-5829-b7bc-0ed4d7bef71c","evidence_kind":"source_excerpt","locator":"Lines 336-342","start_line":336,"end_line":342,"excerpt":"## fast-tfeb-dephosphorylation\nRemoving phosphate marks let a regulator reach the nucleus.\nCalcineurin bound and dephosphorylated TFEB, promoting its nuclear translocation.\nModel: Genetic and pharmacological perturbation of the calcineurin–TFEB pathway.\nLimitations: This establishes a regulatory route, not a fixed fasting schedule.\nEvidence access: Primary abstract\nLysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25720963/ · DOI 10.1038/ncb3114","model_system":"Genetic and pharmacological perturbation of the calcineurin–TFEB pathway.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}