Component
Symbol-search performance
Symbol-search performance. Study-specific scope and measurement methods are recorded with each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Iodine treatment improved symbol search performance compared with placebo at 24 weeks (reported adjusted P<0.0001).
Experimental context and source evidence
- availability_state
- nutrient_deficiency Imported condition classification; unverified.
- cross_nutrient
- false
- evidence_location
- Primary full PDF Methods, Results, Tables 1–2 and Discussion, pp.108–114.
- experimental_model
- Randomized double-blind placebo-controlled 24-week trial in 310 moderately iodine-deficient Albanian children aged 10–12
- exposure
- One supervised oral dose of iodized poppyseed oil containing 400 mg iodine versus sunflower-oil placebo; baseline median urinary iodine 43 micrograms/L, 87% goitrous; iodine 159/placebo 151 randomized.
- limitations
- Baseline groups differed on four psychological tests; analyses adjusted for baseline score, school and sex. Follow-up was 24 weeks, with no proof of lasting IQ or school-performance improvement. Symbol-search test-retest reliability was modest. Dose is a historical depot intervention, not daily intake. One of four improved tests in a seven-test battery; a positive result on this task is not an effect size for general intelligence.
- nutrient_topic
- Iodine research collection; topical membership is not evidence of a direct dietary effect. · Iodine
- organism
- Homo sapiens
- plain_language
- In this study, iodine repletion improved symbol search.
- primary_references
- [iod-clin-albania2006] Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. (2006). https://pubmed.ncbi.nlm.nih.gov/16400058/ DOI: 10.1093/ajcn/83.1.108
- tissue_or_cell_type
- Thyroid hormones and cognitive/motor testing
- trigger_kind
- nutrient_deficiency Imported condition classification; unverified.
Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17) · lines 1328–1340
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled 24-week trial in 310 moderately iodine-deficient Albanian children aged 10–12 · source_derived_draft · unverified_draft
### iod-clin-albania-symbol Iodine treatment improved symbol search performance compared with placebo at 24 weeks (reported adjusted P<0.0001). Condition category: nutrient_deficiency nutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect. plain_language: In this study, iodine repletion improved symbol search. organism: Homo sapiens tissue_or_cell_type: Thyroid hormones and cognitive/motor testing experimental_model: Randomized double-blind placebo-controlled 24-week trial in 310 moderately iodine-deficient Albanian children aged 10–12 limitations: Baseline groups differed on four psychological tests; analyses adjusted for baseline score, school and sex. Follow-up was 24 weeks, with no proof of lasting IQ or school-performance improvement. Symbol-search test-retest reliability was modest. Dose is a historical depot intervention, not daily intake. One of four improved tests in a seven-test battery; a positive result on this task is not an effect size for general intelligence. exposure: One supervised oral dose of iodized poppyseed oil containing 400 mg iodine versus sunflower-oil placebo; baseline median urinary iodine 43 micrograms/L, 87% goitrous; iodine 159/placebo 151 randomized. cross_nutrient: false evidence_location: Primary full PDF Methods, Results, Tables 1–2 and Discussion, pp.108–114. [iod-clin-albania2006] Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. (2006). https://pubmed.ncbi.nlm.nih.gov/16400058/ DOI: 10.1093/ajcn/83.1.108
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.