{"id":"96c190f6-f41b-5e23-b0e0-f26503e5e538","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-albania-symbol","predicate":"repletion-improves","statement":"Iodine treatment improved symbol search performance compared with placebo at 24 weeks (reported adjusted P<0.0001).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"850502f3-14b0-55b1-91ce-bd46e07c4cf7","mechanism_event_label":"In this study, iodine repletion improved symbol search.","subject":{"id":"a6c8a491-944e-5f9a-9caf-6e9063b9030f","slug":"iodized-oil","display_name":"Iodized oil preparation","entity_type_key":"chemical_species"},"object":{"id":"90cd2b93-dd78-5b59-bc9f-2405988d05ef","slug":"symbol-search-performance","display_name":"Symbol-search performance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"850502f3-14b0-55b1-91ce-bd46e07c4cf7","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-albania-symbol-event","event_type":"observed_intervention","label":"In this study, iodine repletion improved symbol search.","description":"Iodine treatment improved symbol search performance compared with placebo at 24 weeks (reported adjusted P<0.0001).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"repleted nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a6c8a491-944e-5f9a-9caf-6e9063b9030f","slug":"iodized-oil","display_name":"Iodized oil preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"90cd2b93-dd78-5b59-bc9f-2405988d05ef","slug":"symbol-search-performance","display_name":"Symbol-search performance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary full PDF Methods, Results, Tables 1–2 and Discussion, pp.108–114.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled 24-week trial in 310 moderately iodine-deficient Albanian children aged 10–12","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One supervised oral dose of iodized poppyseed oil containing 400 mg iodine versus sunflower-oil placebo; baseline median urinary iodine 43 micrograms/L, 87% goitrous; iodine 159/placebo 151 randomized.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Baseline groups differed on four psychological tests; analyses adjusted for baseline score, school and sex. 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Follow-up was 24 weeks, with no proof of lasting IQ or school-performance improvement. Symbol-search test-retest reliability was modest. Dose is a historical depot intervention, not daily intake. One of four improved tests in a seven-test battery; a positive result on this task is not an effect size for general intelligence.\nexposure: One supervised oral dose of iodized poppyseed oil containing 400 mg iodine versus sunflower-oil placebo; baseline median urinary iodine 43 micrograms/L, 87% goitrous; iodine 159/placebo 151 randomized.\ncross_nutrient: false\nevidence_location: Primary full PDF Methods, Results, Tables 1–2 and Discussion, pp.108–114.\n[iod-clin-albania2006] Iodine supplementation improves cognition in iodine-deficient schoolchildren in Albania: a randomized, controlled, double-blind study. 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