Component

Systemic sulforaphane exposure measured by study-specific biomarkers

Systemic sulforaphane exposure measured by study-specific biomarkers. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Baseline abundance of the bacterial glucosinolate-conversion operon correlated with serum sulforaphane in exploratory analysis.

    Baseline microbial glucosinolate-operon abundance → Systemic sulforaphane exposure measured by study-specific biomarkers source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/39929977.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92", "start_char": 0, "end_char": 1849, "text_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92"}
    experimental_model
    Randomized double-blind placebo-controlled trial with exploratory microbiome analysis
    exposure
    Daily broccoli sprout extract for 12 weeks
    limitations
    Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human prediabetes; 35 extract and 39 placebo participants analyzed
    plain_language
    Microbial conversion capacity may help explain exposure differences, but this was not a randomized microbial intervention.
    primary_references
    [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w
    tissue_or_cell_type
    Fasting glucose and serum exposure

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1191–1202

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial with exploratory microbiome analysis · source_derived_draft · unverified_draft

    ### sulforaphane-microbiome-response Baseline abundance of the bacterial glucosinolate-conversion operon correlated with serum sulforaphane in exploratory analysis. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: Microbial conversion capacity may help explain exposure differences, but this was not a randomized microbial intervention. organism: Human prediabetes; 35 extract and 39 placebo participants analyzed tissue_or_cell_type: Fasting glucose and serum exposure experimental_model: Randomized double-blind placebo-controlled trial with exploratory microbiome analysis limitations: Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation. exposure: Daily broccoli sprout extract for 12 weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/39929977.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92", "start_char": 0, "end_char": 1849, "text_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92"} [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w
    Complete structured claim and evidence

  2. Myrosinase increased mean urinary-metabolite-based recovery from 18.6% to 39.8%, and early conversion during the first eight hours from 8.0% to 25.4%.

    Glucoraphanin plus active myrosinase preparation → Systemic sulforaphane exposure measured by study-specific biomarkers source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/41692762.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "67e337141c8012ea573d9720d5e4774bfdd1ae098c056b68991752169fbdb32a", "start_char": 0, "end_char": 1248, "text_sha256": "67e337141c8012ea573d9720d5e4774bfdd1ae098c056b68991752169fbdb32a"}
    experimental_model
    Randomized double-blind crossover single-dose study
    exposure
    Broccoli seed glucoraphanin with versus without mustard myrosinase; both arms contained ascorbic acid
    limitations
    Both arms included ascorbic acid, so its independent benefit cannot be inferred; conversion biomarker is not clinical efficacy.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 16 adults, nine women and seven men
    plain_language
    A recent controlled product comparison confirms the importance of enzyme activity.
    primary_references
    [sulforaphane-p41692762] Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study. (2026). https://pubmed.ncbi.nlm.nih.gov/41692762/ DOI: 10.1038/s41598-026-39389-4
    tissue_or_cell_type
    Urinary metabolites and fecal microbial genes

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 996–1007

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind crossover single-dose study · source_derived_draft · unverified_draft

    ### sulforaphane-mustard-seed-trial Myrosinase increased mean urinary-metabolite-based recovery from 18.6% to 39.8%, and early conversion during the first eight hours from 8.0% to 25.4%. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: A recent controlled product comparison confirms the importance of enzyme activity. organism: Human, 16 adults, nine women and seven men tissue_or_cell_type: Urinary metabolites and fecal microbial genes experimental_model: Randomized double-blind crossover single-dose study limitations: Both arms included ascorbic acid, so its independent benefit cannot be inferred; conversion biomarker is not clinical efficacy. exposure: Broccoli seed glucoraphanin with versus without mustard myrosinase; both arms contained ascorbic acid evidence_span: {"source_cache": "artifacts/sulforaphane-research/41692762.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "67e337141c8012ea573d9720d5e4774bfdd1ae098c056b68991752169fbdb32a", "start_char": 0, "end_char": 1248, "text_sha256": "67e337141c8012ea573d9720d5e4774bfdd1ae098c056b68991752169fbdb32a"} [sulforaphane-p41692762] Exogenous myrosinase from mustard seed increases bioavailability of sulforaphane from a glucoraphanin-rich broccoli seed extract in a randomized clinical study. (2026). https://pubmed.ncbi.nlm.nih.gov/41692762/ DOI: 10.1038/s41598-026-39389-4
    Complete structured claim and evidence

  3. In the broccoli meal study, estimated sulforaphane bioavailability was 37% raw versus 3.4% cooked, with plasma peaks at 1.6 versus 6 hours.

    Broccoli food preparation, cooking conditions specified per study → Systemic sulforaphane exposure measured by study-specific biomarkers source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/18950181.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ef43f16e111c240c46a1cc958ef8777a466694e04916e7c96ffe6bf7047c826c", "start_char": 0, "end_char": 937, "text_sha256": "ef43f16e111c240c46a1cc958ef8777a466694e04916e7c96ffe6bf7047c826c"}
    experimental_model
    Randomized open crossover food trial
    exposure
    200 g crushed raw versus cooked broccoli with a meal
    limitations
    Small food experiment; processing-specific exposure, not a long-term health outcome.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, eight men
    plain_language
    The preparation changed both the amount and timing of exposure.
    primary_references
    [sulforaphane-p18950181] Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. (2008). https://pubmed.ncbi.nlm.nih.gov/18950181/ DOI: 10.1021/jf801989e
    tissue_or_cell_type
    Blood and urinary exposure

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 970–981

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized open crossover food trial · source_derived_draft · unverified_draft

    ### sulforaphane-raw-cooked In the broccoli meal study, estimated sulforaphane bioavailability was 37% raw versus 3.4% cooked, with plasma peaks at 1.6 versus 6 hours. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: The preparation changed both the amount and timing of exposure. organism: Human, eight men tissue_or_cell_type: Blood and urinary exposure experimental_model: Randomized open crossover food trial limitations: Small food experiment; processing-specific exposure, not a long-term health outcome. exposure: 200 g crushed raw versus cooked broccoli with a meal evidence_span: {"source_cache": "artifacts/sulforaphane-research/18950181.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "ef43f16e111c240c46a1cc958ef8777a466694e04916e7c96ffe6bf7047c826c", "start_char": 0, "end_char": 937, "text_sha256": "ef43f16e111c240c46a1cc958ef8777a466694e04916e7c96ffe6bf7047c826c"} [sulforaphane-p18950181] Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. (2008). https://pubmed.ncbi.nlm.nih.gov/18950181/ DOI: 10.1021/jf801989e
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards