{"id":"03f48f2b-fc2e-5948-8469-daea1f5623a5","stable_key":"44eaeae5-557a-552b-8998-884f30462e2a:sulforaphane-microbiome-response","predicate":"was_associated_with","statement":"Baseline abundance of the bacterial glucosinolate-conversion operon correlated with serum sulforaphane in exploratory analysis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"81bd12b9-1ad2-5fdb-a595-41629d3a419d","mechanism_event_label":"Microbial conversion capacity may help explain exposure differences, but this was not a randomized microbial intervention.","subject":{"id":"67e26271-a3ef-55a2-9912-cc91cd74c77c","slug":"gut-glucosinolate-operon-abundance","display_name":"Baseline microbial glucosinolate-operon abundance","entity_type_key":"cellular_process"},"object":{"id":"7663ed75-8dcf-5bab-9034-ab1afef5268b","slug":"sulforaphane-systemic-exposure","display_name":"Systemic sulforaphane exposure measured by study-specific biomarkers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"81bd12b9-1ad2-5fdb-a595-41629d3a419d","stable_key":"44eaeae5-557a-552b-8998-884f30462e2a:sulforaphane-microbiome-response-event","event_type":"biochemical_relationship","label":"Microbial conversion capacity may help explain exposure differences, but this was not a randomized microbial intervention.","description":"Baseline abundance of the bacterial glucosinolate-conversion operon correlated with serum sulforaphane in exploratory analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"67e26271-a3ef-55a2-9912-cc91cd74c77c","slug":"gut-glucosinolate-operon-abundance","display_name":"Baseline microbial glucosinolate-operon abundance","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7663ed75-8dcf-5bab-9034-ab1afef5268b","slug":"sulforaphane-systemic-exposure","display_name":"Systemic sulforaphane exposure measured by study-specific biomarkers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sulforaphane-research/39929977.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92\", \"start_char\": 0, \"end_char\": 1849, \"text_sha256\": \"525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind placebo-controlled trial with exploratory microbiome analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Daily broccoli sprout extract for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sulforaphane","display_name":"Sulforaphane / SFN, stereochemistry specified per study","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human prediabetes; 35 extract and 39 placebo participants analyzed","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Microbial conversion capacity may help explain exposure differences, but this was not a randomized microbial intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fasting glucose and serum exposure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6d7ffcf8-adcd-5c2c-88d0-531f85b9231a","evidence_kind":"source_excerpt","locator":"Lines 1191-1202","start_line":1191,"end_line":1202,"excerpt":"### sulforaphane-microbiome-response\nBaseline abundance of the bacterial glucosinolate-conversion operon correlated with serum sulforaphane in exploratory analysis.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Microbial conversion capacity may help explain exposure differences, but this was not a randomized microbial intervention.\norganism: Human prediabetes; 35 extract and 39 placebo participants analyzed\ntissue_or_cell_type: Fasting glucose and serum exposure\nexperimental_model: Randomized double-blind placebo-controlled trial with exploratory microbiome analysis\nlimitations: Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation.\nexposure: Daily broccoli sprout extract for 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/39929977.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92\", \"start_char\": 0, \"end_char\": 1849, \"text_sha256\": \"525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92\"}\n[sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w","model_system":"Randomized double-blind placebo-controlled trial with exploratory microbiome analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. 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