Component
Sodium benzoate
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
During sodium-benzoate treatment of five neonatal-onset nonketotic-hyperglycinemia patients, three of four tested had plasma carnitine deficiency and benzoylcarnitine was detected.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Small treated human case series.
- limitations
- No untreated comparator; association does not quantify an ordinary food-preservative effect.
- nutrient_topic
- Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
- plain_language
- Using one conjugation route can be accompanied by loss of another nutrient.
- primary_references
- Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410
Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 314–320
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Small treated human case series. · source_derived_draft · unverified_draft
## glycine-benzoate-carnitine Using one conjugation route can be accompanied by loss of another nutrient. During sodium-benzoate treatment of five neonatal-onset nonketotic-hyperglycinemia patients, three of four tested had plasma carnitine deficiency and benzoylcarnitine was detected. Model: Small treated human case series. Limitations: No untreated comparator; association does not quantify an ordinary food-preservative effect. Evidence access: Primary abstract Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410
Complete structured claim and evidence
Where it participates (unsigned role)
L-carnitine treatment normalized plasma free carnitine in the reported benzoate-treated patients; increased glycine conjugation was a tendency rather than a definitive outcome.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human nonketotic-hyperglycinemia case series.
- limitations
- Do not infer a general glycine/carnitine supplement combination or a dosing recommendation.
- nutrient_topic
- Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Glycine
- plain_language
- A measured treatment-associated nutrient deficit responded to replacement.
- primary_references
- Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410
Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19) · lines 322–328
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human nonketotic-hyperglycinemia case series. · source_derived_draft · unverified_draft
## glycine-benzoate-carnitine-repletion A measured treatment-associated nutrient deficit responded to replacement. L-carnitine treatment normalized plasma free carnitine in the reported benzoate-treated patients; increased glycine conjugation was a tendency rather than a definitive outcome. Model: Human nonketotic-hyperglycinemia case series. Limitations: Do not infer a general glycine/carnitine supplement combination or a dosing recommendation. Evidence access: Primary abstract Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.