{"id":"41beae39-bec5-5f50-852e-5fddf0689977","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-benzoate-carnitine","predicate":"associates_with","statement":"During sodium-benzoate treatment of five neonatal-onset nonketotic-hyperglycinemia patients, three of four tested had plasma carnitine deficiency and benzoylcarnitine was detected.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c273a670-10d8-51c2-8898-8a4a53252aed","mechanism_event_label":"Using one conjugation route can be accompanied by loss of another nutrient.","subject":{"id":"6872a437-54b0-5999-8736-f7edbba1fc7d","slug":"sodium-benzoate","display_name":"Sodium benzoate","entity_type_key":"drug"},"object":{"id":"22b945da-9e14-5bc9-8d34-2240546562ed","slug":"human-benzoate-carnitine-depletion","display_name":"Carnitine depletion during benzoate treatment of nonketotic hyperglycinemia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c273a670-10d8-51c2-8898-8a4a53252aed","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-benzoate-carnitine-event","event_type":"observed_relationship","label":"Using one conjugation route can be accompanied by loss of another nutrient.","description":"During sodium-benzoate treatment of five neonatal-onset nonketotic-hyperglycinemia patients, three of four tested had plasma carnitine deficiency and benzoylcarnitine was detected.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6872a437-54b0-5999-8736-f7edbba1fc7d","slug":"sodium-benzoate","display_name":"Sodium benzoate","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"22b945da-9e14-5bc9-8d34-2240546562ed","slug":"human-benzoate-carnitine-depletion","display_name":"Carnitine depletion during benzoate treatment of nonketotic hyperglycinemia","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small treated human case series.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No untreated comparator; association does not quantify an ordinary food-preservative effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Using one conjugation route can be accompanied by loss of another nutrient.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1d08020d-0088-5f7a-bebe-913ed0015e35","evidence_kind":"source_excerpt","locator":"Lines 314-320","start_line":314,"end_line":320,"excerpt":"## glycine-benzoate-carnitine\nUsing one conjugation route can be accompanied by loss of another nutrient.\nDuring sodium-benzoate treatment of five neonatal-onset nonketotic-hyperglycinemia patients, three of four tested had plasma carnitine deficiency and benzoylcarnitine was detected.\nModel: Small treated human case series.\nLimitations: No untreated comparator; association does not quantify an ordinary food-preservative effect.\nEvidence access: Primary abstract\nBenzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410","model_system":"Small treated human case series.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"4fabd2fc8e71ca156c91023e7340be3f5a02ae03e91d3a24b231c2adfb0de0aa","revision_id":"24801e49-34a8-53c3-bdf5-b59143441450","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}