{"id":"a3b7d3ff-f633-5009-9bdc-f4cefd59f181","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-benzoate-carnitine-repletion","predicate":"restores_tested","statement":"L-carnitine treatment normalized plasma free carnitine in the reported benzoate-treated patients; increased glycine conjugation was a tendency rather than a definitive outcome.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7769f910-ebb3-582a-9694-503e10b57752","mechanism_event_label":"A measured treatment-associated nutrient deficit responded to replacement.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"c1cef649-5bbf-5c91-91e2-4af09e6d0989","slug":"human-benzoate-free-carnitine","display_name":"Free plasma carnitine in benzoate-treated patients","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7769f910-ebb3-582a-9694-503e10b57752","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-benzoate-carnitine-repletion-event","event_type":"observed_relationship","label":"A measured treatment-associated nutrient deficit responded to replacement.","description":"L-carnitine treatment normalized plasma free carnitine in the reported benzoate-treated patients; increased glycine conjugation was a tendency rather than a definitive outcome.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c1cef649-5bbf-5c91-91e2-4af09e6d0989","slug":"human-benzoate-free-carnitine","display_name":"Free plasma carnitine in benzoate-treated patients","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6872a437-54b0-5999-8736-f7edbba1fc7d","slug":"sodium-benzoate","display_name":"Sodium benzoate","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human nonketotic-hyperglycinemia case series.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Do not infer a general glycine/carnitine supplement combination or a dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A measured treatment-associated nutrient deficit responded to replacement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Benzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c137f379-7627-57a5-9cf8-566df74fc9e0","evidence_kind":"source_excerpt","locator":"Lines 322-328","start_line":322,"end_line":328,"excerpt":"## glycine-benzoate-carnitine-repletion\nA measured treatment-associated nutrient deficit responded to replacement.\nL-carnitine treatment normalized plasma free carnitine in the reported benzoate-treated patients; increased glycine conjugation was a tendency rather than a definitive outcome.\nModel: Human nonketotic-hyperglycinemia case series.\nLimitations: Do not infer a general glycine/carnitine supplement combination or a dosing recommendation.\nEvidence access: Primary abstract\nBenzoate therapy and carnitine deficiency in non-ketotic hyperglycinemia. · 1995 · https://pubmed.ncbi.nlm.nih.gov/8585564/ · DOI 10.1002/ajmg.1320590410","model_system":"Human nonketotic-hyperglycinemia case series.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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