Component
Serum unmetabolized folic acid concentration
Measured unchanged folic acid in serum; biomarker, not a distinct molecular species.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
During the tested five-day fortified cereal/bread regimen, unchanged folic acid appeared in serum at 266 micrograms per meal.
Experimental context and source evidence
- experimental_model
- Acute fortified-food/supplement exposure in volunteers
- exposure
- Acute fortified-food dosing schedules
- limitations
- Study-specific detectability; not a universal threshold or evidence of toxicity.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- Some ingested folic acid circulated unchanged.
- primary_references
- [kelly1997] Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements (1997). https://pubmed.ncbi.nlm.nih.gov/9174474/ DOI: 10.1093/ajcn/65.6.1790
- tissue_or_cell_type
- Serum in young and older volunteers
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 411–421
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Acute fortified-food/supplement exposure in volunteers · source_derived_draft · unverified_draft
### folate-kelly-postprandial-umfa During the tested five-day fortified cereal/bread regimen, unchanged folic acid appeared in serum at 266 micrograms per meal. Condition category: normal nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Some ingested folic acid circulated unchanged. organism: Homo sapiens tissue_or_cell_type: Serum in young and older volunteers experimental_model: Acute fortified-food/supplement exposure in volunteers limitations: Study-specific detectability; not a universal threshold or evidence of toxicity. exposure: Acute fortified-food dosing schedules [kelly1997] Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements (1997). https://pubmed.ncbi.nlm.nih.gov/9174474/ DOI: 10.1093/ajcn/65.6.1790
Complete structured claim and evidenceUMFA above the 0.3 nmol/L detection limit occurred in over 95% of NHANES supplement users and nonusers; fasting status influenced concentrations.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- experimental_model
- Cross-sectional NHANES 2007-2008 serum vitamer measurements
- exposure
- Cross-sectional fortified-population sampling
- limitations
- Detection depends on assay sensitivity and sampling; no adverse outcome tested.
- nutrient_topic
- Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. · Folate (vitamin B9)
- organism
- Homo sapiens
- plain_language
- A detectable blood marker is not by itself a harm threshold.
- primary_references
- [pfeiffer2015] Unmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adults (2015). https://pubmed.ncbi.nlm.nih.gov/25733468/ DOI: 10.3945/jn.114.201210
- tissue_or_cell_type
- Serum; NHANES 2007-2008
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17) · lines 423–433
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Cross-sectional NHANES 2007-2008 serum vitamer measurements · source_derived_draft · unverified_draft
### folate-nhanes-umfa-detection UMFA above the 0.3 nmol/L detection limit occurred in over 95% of NHANES supplement users and nonusers; fasting status influenced concentrations. Condition category: biomarker_context nutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A detectable blood marker is not by itself a harm threshold. organism: Homo sapiens tissue_or_cell_type: Serum; NHANES 2007-2008 experimental_model: Cross-sectional NHANES 2007-2008 serum vitamer measurements limitations: Detection depends on assay sensitivity and sampling; no adverse outcome tested. exposure: Cross-sectional fortified-population sampling [pfeiffer2015] Unmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adults (2015). https://pubmed.ncbi.nlm.nih.gov/25733468/ DOI: 10.3945/jn.114.201210
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.