{"id":"163d69d7-7909-5fdc-8fab-bbcbcf7082ca","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-kelly-postprandial-umfa","predicate":"increases","statement":"During the tested five-day fortified cereal/bread regimen, unchanged folic acid appeared in serum at 266 micrograms per meal.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0342c5d3-4a49-5a33-bcdf-66b5d1c62439","mechanism_event_label":"Some ingested folic acid circulated unchanged.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"8aa8eab2-b237-5604-9acc-95c1e745f7f1","slug":"serum-unmetabolized-folic-acid","display_name":"Serum unmetabolized folic acid concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0342c5d3-4a49-5a33-bcdf-66b5d1c62439","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-kelly-postprandial-umfa-event","event_type":"observed_intervention","label":"Some ingested folic acid circulated unchanged.","description":"During the tested five-day fortified cereal/bread regimen, unchanged folic acid appeared in serum at 266 micrograms per meal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8aa8eab2-b237-5604-9acc-95c1e745f7f1","slug":"serum-unmetabolized-folic-acid","display_name":"Serum unmetabolized folic acid concentration","entity_type_key":"cellular_process"},"role":"object","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Acute fortified-food/supplement exposure in volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Acute fortified-food dosing schedules","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study-specific detectability; not a universal threshold or evidence of toxicity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"folate","display_name":"Folate (vitamin B9)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Some ingested folic acid circulated unchanged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[kelly1997] Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements (1997). https://pubmed.ncbi.nlm.nih.gov/9174474/ DOI: 10.1093/ajcn/65.6.1790","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum in young and older volunteers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"419f9532-72ec-5a3e-bec4-161895b02476","evidence_kind":"source_excerpt","locator":"Lines 411-421","start_line":411,"end_line":421,"excerpt":"### folate-kelly-postprandial-umfa\nDuring the tested five-day fortified cereal/bread regimen, unchanged folic acid appeared in serum at 266 micrograms per meal.\nCondition category: normal\nnutrient_topic: Folate and folic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Some ingested folic acid circulated unchanged.\norganism: Homo sapiens\ntissue_or_cell_type: Serum in young and older volunteers\nexperimental_model: Acute fortified-food/supplement exposure in volunteers\nlimitations: Study-specific detectability; not a universal threshold or evidence of toxicity.\nexposure: Acute fortified-food dosing schedules\n[kelly1997] Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements (1997). https://pubmed.ncbi.nlm.nih.gov/9174474/ DOI: 10.1093/ajcn/65.6.1790","model_system":"Acute fortified-food/supplement exposure in volunteers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [kelly1997] Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements (1997). https://pubmed.ncbi.nlm.nih.gov/9174474/ DOI: 10.1093/ajcn/65.6.1790","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}