{"id":"e0c6f271-459c-5c94-be08-70f05f002e73","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-nhanes-umfa-detection","predicate":"measured-as","statement":"UMFA above the 0.3 nmol/L detection limit occurred in over 95% of NHANES supplement users and nonusers; fasting status influenced concentrations.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a43bfe78-00a3-52a8-a4e9-bd6341bbe522","mechanism_event_label":"A detectable blood marker is not by itself a harm threshold.","subject":{"id":"d322bfef-5135-599f-82e6-0aa58748dc8b","slug":"folic-acid","display_name":"Folic acid","entity_type_key":"small_molecule"},"object":{"id":"8aa8eab2-b237-5604-9acc-95c1e745f7f1","slug":"serum-unmetabolized-folic-acid","display_name":"Serum unmetabolized folic acid concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a43bfe78-00a3-52a8-a4e9-bd6341bbe522","stable_key":"ec174d5a-4903-5745-8646-df0e9d4265e8:folate-nhanes-umfa-detection-event","event_type":"observed_intervention","label":"A detectable blood marker is not by itself a harm threshold.","description":"UMFA above the 0.3 nmol/L detection limit occurred in over 95% of NHANES supplement users and nonusers; 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no adverse outcome tested.\nexposure: Cross-sectional fortified-population sampling\n[pfeiffer2015] Unmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adults (2015). https://pubmed.ncbi.nlm.nih.gov/25733468/ DOI: 10.3945/jn.114.201210","model_system":"Cross-sectional NHANES 2007-2008 serum vitamer measurements","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pfeiffer2015] Unmetabolized folic acid is detected in nearly all serum samples from US children, adolescents, and adults (2015). https://pubmed.ncbi.nlm.nih.gov/25733468/ DOI: 10.3945/jn.114.201210","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f4ce1a62-9582-5f7a-84f5-a23d0e1bfc68","stable_key":"import-ec174d5a-4903-5745-8646-df0e9d4265e8","title":"Folate and folic acid: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"e564d43989ece1006c95cd0748e9af6fe369074599a2eebba0a99ebff864b0dd","revision_id":"76674a33-b2a1-5e41-b71b-44399038ff7c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}