Component
SARS-CoV-2 main protease / Mpro / 3CLpro
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
A 1.77-angstrom crystal structure showed myricetin covalently attached to catalytic Cys145 of SARS-CoV-2 Mpro.
Experimental context and source evidence
- evidence_access
- Primary full text
- experimental_model
- Purified viral protease crystallography and enzyme screen.
- limitations
- Not proof of antiviral efficacy after eating myricetin or taking a supplement.
- nutrient_topic
- Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
- plain_language
- This target has structural evidence, not docking alone.
- primary_references
- Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. · 2021 · https://pubmed.ncbi.nlm.nih.gov/35287429/ · DOI 10.1021/acsptsci.0c00216
Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 316–322
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Purified viral protease crystallography and enzyme screen. · source_derived_draft · unverified_draft
## myricetin-mpro-adduct This target has structural evidence, not docking alone. A 1.77-angstrom crystal structure showed myricetin covalently attached to catalytic Cys145 of SARS-CoV-2 Mpro. Model: Purified viral protease crystallography and enzyme screen. Limitations: Not proof of antiviral efficacy after eating myricetin or taking a supplement. Evidence access: Primary full text Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. · 2021 · https://pubmed.ncbi.nlm.nih.gov/35287429/ · DOI 10.1021/acsptsci.0c00216
Complete structured claim and evidenceReduced glutathione prevented myricetin–Mpro conjugate formation and canceled the inhibitory effect in the tested assay.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_access
- Primary full text
- experimental_model
- Purified viral protease; product chromatography, mass spectrometry and quinone staining.
- limitations
- Cell-free competition does not quantify GSH consumption or establish antiviral benefit in vivo.
- nutrient_topic
- Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Myricetin
- plain_language
- A cellular antioxidant can intercept a reaction that inhibits another protein.
- primary_references
- Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro. · 2021 · https://pubmed.ncbi.nlm.nih.gov/35425933/ · DOI 10.1016/j.arres.2021.100021
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 324–330
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Purified viral protease; product chromatography, mass spectrometry and quinone staining. · source_derived_draft · unverified_draft
## myricetin-mpro-gsh A cellular antioxidant can intercept a reaction that inhibits another protein. Reduced glutathione prevented myricetin–Mpro conjugate formation and canceled the inhibitory effect in the tested assay. Model: Purified viral protease; product chromatography, mass spectrometry and quinone staining. Limitations: Cell-free competition does not quantify GSH consumption or establish antiviral benefit in vivo. Evidence access: Primary full text Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro. · 2021 · https://pubmed.ncbi.nlm.nih.gov/35425933/ · DOI 10.1016/j.arres.2021.100021
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.