{"id":"3b40727d-099a-5b8a-a69c-20e4985dadc1","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mpro-gsh","predicate":"blocks_myricetin_adduction","statement":"Reduced glutathione prevented myricetin–Mpro conjugate formation and canceled the inhibitory effect in the tested assay.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"207b6253-95f3-536c-86c2-46f8bb838e02","mechanism_event_label":"A cellular antioxidant can intercept a reaction that inhibits another protein.","subject":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"object":{"id":"f7bd5f06-540c-5c92-8574-30a20168c107","slug":"sars-cov-2-mpro","display_name":"SARS-CoV-2 main protease / Mpro / 3CLpro","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"207b6253-95f3-536c-86c2-46f8bb838e02","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mpro-gsh-event","event_type":"observed_relationship","label":"A cellular antioxidant can intercept a reaction that inhibits another protein.","description":"Reduced glutathione prevented myricetin–Mpro conjugate formation and canceled the inhibitory effect in the tested assay.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f7bd5f06-540c-5c92-8574-30a20168c107","slug":"sars-cov-2-mpro","display_name":"SARS-CoV-2 main protease / Mpro / 3CLpro","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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