{"id":"447e6794-efb9-5737-b572-b0bb8a0b53ba","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mpro-adduct","predicate":"covalently_binds","statement":"A 1.77-angstrom crystal structure showed myricetin covalently attached to catalytic Cys145 of SARS-CoV-2 Mpro.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"61bd56a5-0d87-595e-bdee-2e445ae78f2c","mechanism_event_label":"This target has structural evidence, not docking alone.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"f7bd5f06-540c-5c92-8574-30a20168c107","slug":"sars-cov-2-mpro","display_name":"SARS-CoV-2 main protease / Mpro / 3CLpro","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"61bd56a5-0d87-595e-bdee-2e445ae78f2c","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-mpro-adduct-event","event_type":"observed_relationship","label":"This target has structural evidence, not docking alone.","description":"A 1.77-angstrom crystal structure showed myricetin covalently attached to catalytic Cys145 of SARS-CoV-2 Mpro.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f7bd5f06-540c-5c92-8574-30a20168c107","slug":"sars-cov-2-mpro","display_name":"SARS-CoV-2 main protease / Mpro / 3CLpro","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified viral protease crystallography and enzyme screen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not proof of antiviral efficacy after eating myricetin or taking a supplement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"This target has structural evidence, not docking alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Identification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. · 2021 · https://pubmed.ncbi.nlm.nih.gov/35287429/ · DOI 10.1021/acsptsci.0c00216","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"26b323f1-ff5f-5873-b4cd-323c13d36016","evidence_kind":"source_excerpt","locator":"Lines 316-322","start_line":316,"end_line":322,"excerpt":"## myricetin-mpro-adduct\nThis target has structural evidence, not docking alone.\nA 1.77-angstrom crystal structure showed myricetin covalently attached to catalytic Cys145 of SARS-CoV-2 Mpro.\nModel: Purified viral protease crystallography and enzyme screen.\nLimitations: Not proof of antiviral efficacy after eating myricetin or taking a supplement.\nEvidence access: Primary full text\nIdentification of Inhibitors of SARS-CoV-2 3CL-Pro Enzymatic Activity Using a Small Molecule in Vitro Repurposing Screen. · 2021 · https://pubmed.ncbi.nlm.nih.gov/35287429/ · DOI 10.1021/acsptsci.0c00216","model_system":"Purified viral protease crystallography and enzyme screen.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}