Component
Serum amyloid A1
Serum amyloid A1; specific protein identity, with organism and perturbation supplied in each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Recombinant SAA1 restored impaired Th17 cytokine output in cultured lamina propria cells from epithelial Rarb mutants.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_locator
- Figure 4E
- experimental_model
- Mouse MODE-K cells and intestinal epithelial Rarb deletion.
- exposure
- rSAA1 during 4-hour stimulation
- limitations
- Rescue does not establish delivery of retinol to Th17 cells.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Adding an epithelial-associated mediator rescued the measured immune output.
- primary_references
- [va-gattu-2019] Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6561173/ DOI: 10.1073/pnas.1812069116
- tissue_or_cell_type
- Ex vivo intestinal lamina propria cells
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1344–1355
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse MODE-K cells and intestinal epithelial Rarb deletion. · source_derived_draft · unverified_draft
### va-sig-saa1-rescue-th17 Recombinant SAA1 restored impaired Th17 cytokine output in cultured lamina propria cells from epithelial Rarb mutants. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: Adding an epithelial-associated mediator rescued the measured immune output. organism: Mus musculus tissue_or_cell_type: Ex vivo intestinal lamina propria cells experimental_model: Mouse MODE-K cells and intestinal epithelial Rarb deletion. limitations: Rescue does not establish delivery of retinol to Th17 cells. evidence_locator: Figure 4E exposure: rSAA1 during 4-hour stimulation [va-gattu-2019] Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6561173/ DOI: 10.1073/pnas.1812069116
Complete structured claim and evidence
Where it participates (unsigned role)
Epithelial Rarb deletion reduced intestinal Th17 IL-17A production without reducing overall Th17 frequency.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_locator
- Figure 4A-D
- experimental_model
- Mouse MODE-K cells and intestinal epithelial Rarb deletion.
- exposure
- Epithelial Rarb deletion
- limitations
- Does not establish a complete retinol-transfer chain.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- A receptor in epithelial cells helps neighboring immune cells function.
- primary_references
- [va-gattu-2019] Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6561173/ DOI: 10.1073/pnas.1812069116
- tissue_or_cell_type
- Intestinal lamina propria
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 1331–1342
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Mouse MODE-K cells and intestinal epithelial Rarb deletion. · source_derived_draft · unverified_draft
### va-sig-rarb-th17-effector Epithelial Rarb deletion reduced intestinal Th17 IL-17A production without reducing overall Th17 frequency. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: A receptor in epithelial cells helps neighboring immune cells function. organism: Mus musculus tissue_or_cell_type: Intestinal lamina propria experimental_model: Mouse MODE-K cells and intestinal epithelial Rarb deletion. limitations: Does not establish a complete retinol-transfer chain. evidence_locator: Figure 4A-D exposure: Epithelial Rarb deletion [va-gattu-2019] Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6561173/ DOI: 10.1073/pnas.1812069116
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.