{"id":"aba800ea-1ad8-5e77-a6e7-f611e209d0e2","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-rarb-th17-effector","predicate":"supports","statement":"Epithelial Rarb deletion reduced intestinal Th17 IL-17A production without reducing overall Th17 frequency.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"70127219-16dc-5fcb-8d0a-beb98a4cd402","mechanism_event_label":"A receptor in epithelial cells helps neighboring immune cells function.","subject":{"id":"1ab58d8f-c076-5814-ac44-1492046497ae","slug":"rarb","display_name":"Retinoic acid receptor beta","entity_type_key":"protein"},"object":{"id":"c5e6297a-476c-5e7d-bdd8-26dfe9fd0c2e","slug":"il17a","display_name":"Interleukin 17A","entity_type_key":"cytokine"},"evidence_count":1,"mechanism_event":{"id":"70127219-16dc-5fcb-8d0a-beb98a4cd402","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-rarb-th17-effector-event","event_type":"biochemical_relationship","label":"A receptor in epithelial cells helps neighboring immune cells function.","description":"Epithelial Rarb deletion reduced intestinal Th17 IL-17A production without reducing overall Th17 frequency.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"nutrient-context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aad93db8-98ee-5a7c-b478-51dee6a09aed","slug":"th17-cell","display_name":"T helper 17 cell","entity_type_key":"cell_type"},"role":"responding-cell","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2a1c969a-3f83-50f1-944d-029c5dc9a759","slug":"saa1","display_name":"Serum amyloid A1","entity_type_key":"protein"},"role":"candidate-mediator","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1ab58d8f-c076-5814-ac44-1492046497ae","slug":"rarb","display_name":"Retinoic acid receptor beta","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"c5e6297a-476c-5e7d-bdd8-26dfe9fd0c2e","slug":"il17a","display_name":"Interleukin 17A","entity_type_key":"cytokine"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-gattu-2019] Epithelial retinoic acid receptor beta regulates serum amyloid A expression and vitamin A-dependent intestinal immunity (2019). https://pmc.ncbi.nlm.nih.gov/articles/PMC6561173/ DOI: 10.1073/pnas.1812069116","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}