Component
Ryanodine receptor 1 / RYR1
Independent biological entity. Read linked claims for experimental scope and context.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Purified skeletal-muscle RyR1 forms an intracellular calcium-release channel with ligand-dependent open and closed states.
Experimental context and source evidence
- compartment_description
- Sarcoplasmic reticulum membrane
- experimental_model
- Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings
- limitations
- Reconstituted channel; the study does not reconstruct voltage-sensor coupling in an intact muscle.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Oryctolagus cuniculus
- plain_language
- RyR1 supplies the skeletal-muscle calcium-release pathway.
- primary_references
- [ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075
- research_relationship_category
- transport
- tissue_or_cell_type
- Skeletal muscle
- transport_effect
- raises An intracellular calcium-release channel: the recorded direction is SR lumen to cytosol.
- transport_or_reaction_direction
- SR lumen to cytosol
- transport_pool
- cytosolic calcium An intracellular calcium-release channel: the recorded direction is SR lumen to cytosol.
Calcium: mechanism-first literature curation (2026-09-17) · lines 652–664
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings · source_derived_draft · unverified_draft
### ca-ryr1-calcium-release Purified skeletal-muscle RyR1 forms an intracellular calcium-release channel with ligand-dependent open and closed states. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: RyR1 supplies the skeletal-muscle calcium-release pathway. organism: Oryctolagus cuniculus tissue_or_cell_type: Skeletal muscle experimental_model: Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings limitations: Reconstituted channel; the study does not reconstruct voltage-sensor coupling in an intact muscle. research_relationship_category: transport transport_or_reaction_direction: SR lumen to cytosol compartment_description: Sarcoplasmic reticulum membrane [ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075
Complete structured claim and evidence
What acts on it
Calcium binds an activating RyR1 site and primes gating; ATP and caffeine increase open-state representation in the experimental preparation.
Experimental context and source evidence
- compartment_description
- Cytosolic channel-regulatory region
- experimental_model
- Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings
- limitations
- Calcium is both a transported ion and a ligand; caffeine-assisted structures do not imply caffeine is required physiologically.
- nutrient_topic
- Calcium research collection; topical membership is not evidence of a direct dietary effect. · Calcium
- organism
- Oryctolagus cuniculus
- plain_language
- Calcium helps regulate the RyR1 gate.
- primary_references
- [ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075
- research_relationship_category
- regulation
- tissue_or_cell_type
- Skeletal-muscle channel preparation
Calcium: mechanism-first literature curation (2026-09-17) · lines 666–677
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings · source_derived_draft · unverified_draft
### ca-ryr1-calcium-gating Calcium binds an activating RyR1 site and primes gating; ATP and caffeine increase open-state representation in the experimental preparation. Condition category: normal nutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Calcium helps regulate the RyR1 gate. organism: Oryctolagus cuniculus tissue_or_cell_type: Skeletal-muscle channel preparation experimental_model: Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings limitations: Calcium is both a transported ion and a ligand; caffeine-assisted structures do not imply caffeine is required physiologically. research_relationship_category: regulation compartment_description: Cytosolic channel-regulatory region [ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.