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presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Sarcoplasmic reticulum membrane","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reconstituted channel; the study does not reconstruct voltage-sensor coupling in an intact muscle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Oryctolagus cuniculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"RyR1 supplies the skeletal-muscle calcium-release pathway.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"research_relationship_category","value_text":"transport","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Skeletal muscle","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"An intracellular calcium-release channel: the recorded direction is SR lumen to cytosol.","entity":null},{"dimension":"transport_or_reaction_direction","value_text":"SR lumen to cytosol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_pool","value_text":"cytosolic calcium","comparator":null,"unit":null,"notes":"An intracellular calcium-release channel: the recorded direction is SR lumen to cytosol.","entity":null}],"evidence":[{"id":"67106f47-0ffd-51c2-8ecc-c764ec0e1335","evidence_kind":"source_excerpt","locator":"Lines 652-664","start_line":652,"end_line":664,"excerpt":"### ca-ryr1-calcium-release\nPurified skeletal-muscle RyR1 forms an intracellular calcium-release channel with ligand-dependent open and closed states.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: RyR1 supplies the skeletal-muscle calcium-release pathway.\norganism: Oryctolagus cuniculus\ntissue_or_cell_type: Skeletal muscle\nexperimental_model: Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings\nlimitations: Reconstituted channel; the study does not reconstruct voltage-sensor coupling in an intact muscle.\nresearch_relationship_category: transport\ntransport_or_reaction_direction: SR lumen to cytosol\ncompartment_description: Sarcoplasmic reticulum membrane\n[ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075","model_system":"Purified rabbit skeletal-muscle RyR1 with calstabin2; cryo-EM and planar-bilayer recordings","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ca-desgeorges2016] Structural Basis for Gating and Activation of RyR1 (2016). https://pubmed.ncbi.nlm.nih.gov/27662087/ DOI: 10.1016/j.cell.2016.08.075","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}