Component
RPE-selective CRALBP loss
RPE-selective CRALBP loss is an experimental or genetic machinery state, not dietary vitamin A deficiency.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
RPE-selective CRALBP deletion slowed bulk visual chromophore regeneration approximately 15-fold in mice.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- Timed RPE-selective knockout; post-bleach HPLC
- limitations
- Bulk recovery mainly reflects rods; not a direct human effect size.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- RPE CRALBP strongly supports replenishment of cis retinal.
- primary_references
- [bassetto-2024] Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors (2024). https://pubmed.ncbi.nlm.nih.gov/38676924/ DOI: 10.1016/j.celrep.2024.114143
- tissue_or_cell_type
- RPE/whole-eye retinoids
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 860–869
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Timed RPE-selective knockout; post-bleach HPLC · source_derived_draft · unverified_draft
### a-vision-rpe-cralbp-chromophore RPE-selective CRALBP deletion slowed bulk visual chromophore regeneration approximately 15-fold in mice. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: RPE CRALBP strongly supports replenishment of cis retinal. organism: Mus musculus tissue_or_cell_type: RPE/whole-eye retinoids experimental_model: Timed RPE-selective knockout; post-bleach HPLC limitations: Bulk recovery mainly reflects rods; not a direct human effect size. [bassetto-2024] Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors (2024). https://pubmed.ncbi.nlm.nih.gov/38676924/ DOI: 10.1016/j.celrep.2024.114143
Complete structured claim and evidenceRPE-selective CRALBP knockout markedly delayed mouse rod dark adaptation after bleaching.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- experimental_model
- ERG recovery after bleaching
- limitations
- Same machinery perturbation as the retinoid measurements.
- nutrient_topic
- Vitamin A research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- The slowed recycling is accompanied by slow rod recovery.
- primary_references
- [bassetto-2024] Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors (2024). https://pubmed.ncbi.nlm.nih.gov/38676924/ DOI: 10.1016/j.celrep.2024.114143
- tissue_or_cell_type
- Rod retina with RPE-selective mutation
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17) · lines 871–880
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · ERG recovery after bleaching · source_derived_draft · unverified_draft
### a-vision-rpe-cralbp-rods RPE-selective CRALBP knockout markedly delayed mouse rod dark adaptation after bleaching. Condition category: machinery_impairment nutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect. plain_language: The slowed recycling is accompanied by slow rod recovery. organism: Mus musculus tissue_or_cell_type: Rod retina with RPE-selective mutation experimental_model: ERG recovery after bleaching limitations: Same machinery perturbation as the retinoid measurements. [bassetto-2024] Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors (2024). https://pubmed.ncbi.nlm.nih.gov/38676924/ DOI: 10.1016/j.celrep.2024.114143
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.