{"id":"341961f4-6309-524f-8b7e-1bf2e9db8ad4","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-rpe-cralbp-rods","predicate":"delays","statement":"RPE-selective CRALBP knockout markedly delayed mouse rod dark adaptation after bleaching.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"fe058ddb-818b-5b50-95ca-d6f6a1995ad3","mechanism_event_label":"The slowed recycling is accompanied by slow rod recovery.","subject":{"id":"3978c34f-46cc-5f1b-a397-4225f911adf1","slug":"rlbp1-rpe-loss","display_name":"RPE-selective CRALBP loss","entity_type_key":"protein_state"},"object":{"id":"cc277d25-a552-5c47-9c82-a642fbc2c4a8","slug":"rod-dark-adaptation","display_name":"Rod dark adaptation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fe058ddb-818b-5b50-95ca-d6f6a1995ad3","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:a-vision-rpe-cralbp-rods-event","event_type":"biochemical_relationship","label":"The slowed recycling is accompanied by slow rod recovery.","description":"RPE-selective CRALBP knockout markedly delayed mouse rod dark adaptation after bleaching.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3978c34f-46cc-5f1b-a397-4225f911adf1","slug":"rlbp1-rpe-loss","display_name":"RPE-selective CRALBP loss","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"cc277d25-a552-5c47-9c82-a642fbc2c4a8","slug":"rod-dark-adaptation","display_name":"Rod dark adaptation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"ERG recovery after bleaching","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Same machinery perturbation as the retinoid measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The slowed recycling is accompanied by slow rod recovery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[bassetto-2024] Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors (2024). https://pubmed.ncbi.nlm.nih.gov/38676924/ DOI: 10.1016/j.celrep.2024.114143","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Rod retina with RPE-selective mutation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"04b859ec-bcd1-5be6-8eee-59312b22cd52","evidence_kind":"source_excerpt","locator":"Lines 871-880","start_line":871,"end_line":880,"excerpt":"### a-vision-rpe-cralbp-rods\nRPE-selective CRALBP knockout markedly delayed mouse rod dark adaptation after bleaching.\nCondition category: machinery_impairment\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The slowed recycling is accompanied by slow rod recovery.\norganism: Mus musculus\ntissue_or_cell_type: Rod retina with RPE-selective mutation\nexperimental_model: ERG recovery after bleaching\nlimitations: Same machinery perturbation as the retinoid measurements.\n[bassetto-2024] Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors (2024). https://pubmed.ncbi.nlm.nih.gov/38676924/ DOI: 10.1016/j.celrep.2024.114143","model_system":"ERG recovery after bleaching","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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