Component

Retrograde endocannabinoid signalling from postsynaptic neuron to presynaptic terminal

Retrograde endocannabinoid signalling from postsynaptic neuron to presynaptic terminal. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, travelling from the depolarised postsynaptic neuron back to the presynaptic terminal.

    2-Arachidonoylglycerol / 2-AG → Retrograde endocannabinoid signalling from postsynaptic neuron to presynaptic terminal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/thc-research/11279497.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e", "start_char": 0, "end_char": 1117, "text_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e"}
    experimental_model
    Paired recordings in rat hippocampal slices with CB1 antagonists
    exposure
    Postsynaptic depolarisation with presynaptic release measurement
    limitations
    Establishes the direction of the signal, which is what makes the system a feedback loop rather than a transmitter pathway.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Rat
    plain_language
    The signal runs backwards across the synapse, which almost nothing else does.
    primary_references
    [thc-p11279497] Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. (2001). https://pubmed.ncbi.nlm.nih.gov/11279497/ DOI: 10.1038/35069076
    tissue_or_cell_type
    Hippocampus

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 270–281

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Paired recordings in rat hippocampal slices with CB1 antagonists · source_derived_draft · unverified_draft

    ### thc-retrograde-hippocampus Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses, travelling from the depolarised postsynaptic neuron back to the presynaptic terminal. Condition category: normal nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: The signal runs backwards across the synapse, which almost nothing else does. organism: Rat tissue_or_cell_type: Hippocampus experimental_model: Paired recordings in rat hippocampal slices with CB1 antagonists limitations: Establishes the direction of the signal, which is what makes the system a feedback loop rather than a transmitter pathway. exposure: Postsynaptic depolarisation with presynaptic release measurement evidence_span: {"source_cache": "artifacts/thc-research/11279497.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e", "start_char": 0, "end_char": 1117, "text_sha256": "f93de867c0ce253b42d9c248504f4471431310bdc0629fec2a8c49d2eba55e8e"} [thc-p11279497] Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. (2001). https://pubmed.ncbi.nlm.nih.gov/11279497/ DOI: 10.1038/35069076
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Diacylglycerol lipase knock-out mice lost retrograde endocannabinoid signalling and showed reduced adult neurogenesis.

    Experimental diacylglycerol lipase knockout mouse genotype → Adult neurogenesis source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/20147530.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b", "start_char": 0, "end_char": 1709, "text_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b"}
    experimental_model
    Diacylglycerol lipase knock-out mice with synaptic and neurogenesis measurement
    exposure
    Constitutive DAGL deletion
    limitations
    A whole-animal consequence of removing the enzyme, beyond the synaptic recording.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    Without the messenger the brain also makes fewer new neurons.
    primary_references
    [thc-p20147530] Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20147530/ DOI: 10.1523/jneurosci.5693-09.2010
    tissue_or_cell_type
    Hippocampus
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 335–346

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Diacylglycerol lipase knock-out mice with synaptic and neurogenesis measurement · source_derived_draft · unverified_draft

    ### thc-dagl-null-neurogenesis Diacylglycerol lipase knock-out mice lost retrograde endocannabinoid signalling and showed reduced adult neurogenesis. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Without the messenger the brain also makes fewer new neurons. organism: Mouse tissue_or_cell_type: Hippocampus experimental_model: Diacylglycerol lipase knock-out mice with synaptic and neurogenesis measurement limitations: A whole-animal consequence of removing the enzyme, beyond the synaptic recording. exposure: Constitutive DAGL deletion evidence_span: {"source_cache": "artifacts/thc-research/20147530.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b", "start_char": 0, "end_char": 1709, "text_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b"} [thc-p20147530] Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20147530/ DOI: 10.1523/jneurosci.5693-09.2010
    Complete structured claim and evidence

  2. The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission.

    Diacylglycerol lipase alpha / DAGLA → 2-Arachidonoylglycerol / 2-AG source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/thc-research/20159446.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a83e761bbc9dd85f5c5ec84424a876a33b0914b1e6723ed809db0b1854cf00ed", "start_char": 0, "end_char": 1097, "text_sha256": "a83e761bbc9dd85f5c5ec84424a876a33b0914b1e6723ed809db0b1854cf00ed"}
    experimental_model
    Conditional and constitutive DAGLα manipulation with synaptic recordings
    exposure
    DAGLα deletion with retrograde suppression measurement
    limitations
    Assigns the retrograde messenger to a specific enzyme product by removing the enzyme.
    nutrient_topic
    THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
    organism
    Mouse
    plain_language
    One enzyme makes the messenger that carries the backwards signal.
    primary_references
    [thc-p20159446] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. (2010). https://pubmed.ncbi.nlm.nih.gov/20159446/ DOI: 10.1016/j.neuron.2010.01.021
    tissue_or_cell_type
    Brain slices
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 322–333

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Conditional and constitutive DAGLα manipulation with synaptic recordings · source_derived_draft · unverified_draft

    ### thc-dagla-makes-2ag The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: One enzyme makes the messenger that carries the backwards signal. organism: Mouse tissue_or_cell_type: Brain slices experimental_model: Conditional and constitutive DAGLα manipulation with synaptic recordings limitations: Assigns the retrograde messenger to a specific enzyme product by removing the enzyme. exposure: DAGLα deletion with retrograde suppression measurement evidence_span: {"source_cache": "artifacts/thc-research/20159446.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "a83e761bbc9dd85f5c5ec84424a876a33b0914b1e6723ed809db0b1854cf00ed", "start_char": 0, "end_char": 1097, "text_sha256": "a83e761bbc9dd85f5c5ec84424a876a33b0914b1e6723ed809db0b1854cf00ed"} [thc-p20159446] The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. (2010). https://pubmed.ncbi.nlm.nih.gov/20159446/ DOI: 10.1016/j.neuron.2010.01.021
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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