Component
Experimental diacylglycerol lipase knockout mouse genotype
Experimental diacylglycerol lipase knockout mouse genotype. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Diacylglycerol lipase knock-out mice lost retrograde endocannabinoid signalling and showed reduced adult neurogenesis.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/thc-research/20147530.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b", "start_char": 0, "end_char": 1709, "text_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b"}
- experimental_model
- Diacylglycerol lipase knock-out mice with synaptic and neurogenesis measurement
- exposure
- Constitutive DAGL deletion
- limitations
- A whole-animal consequence of removing the enzyme, beyond the synaptic recording.
- nutrient_topic
- THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. · Delta-9-tetrahydrocannabinol / THC
- organism
- Mouse
- plain_language
- Without the messenger the brain also makes fewer new neurons.
- primary_references
- [thc-p20147530] Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20147530/ DOI: 10.1523/jneurosci.5693-09.2010
- tissue_or_cell_type
- Hippocampus
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21) · lines 335–346
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Diacylglycerol lipase knock-out mice with synaptic and neurogenesis measurement · source_derived_draft · unverified_draft
### thc-dagl-null-neurogenesis Diacylglycerol lipase knock-out mice lost retrograde endocannabinoid signalling and showed reduced adult neurogenesis. Condition category: machinery_impairment nutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates. plain_language: Without the messenger the brain also makes fewer new neurons. organism: Mouse tissue_or_cell_type: Hippocampus experimental_model: Diacylglycerol lipase knock-out mice with synaptic and neurogenesis measurement limitations: A whole-animal consequence of removing the enzyme, beyond the synaptic recording. exposure: Constitutive DAGL deletion evidence_span: {"source_cache": "artifacts/thc-research/20147530.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b", "start_char": 0, "end_char": 1709, "text_sha256": "87c25db27ffa9aaeb9ee619ad5adc8fbc8223da9dea61fddc86ad0d455431f2b"} [thc-p20147530] Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. (2010). https://pubmed.ncbi.nlm.nih.gov/20147530/ DOI: 10.1523/jneurosci.5693-09.2010
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
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Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.