Component

Protocolized caloric restriction during ICU refeeding-syndrome management

Protocolized caloric restriction during ICU refeeding-syndrome management. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Days alive after ICU discharge did not differ significantly: 44.8 versus 39.9 days, estimated difference 4.9 days (95% CI −2.3 to 13.6), p=0.19.

    Protocolized caloric restriction during ICU refeeding-syndrome management → Days alive after ICU discharge over 60 days in the refeeding trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/26597128.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6", "start_char": 0, "end_char": 2574, "text_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6"}
    experimental_model
    Multicenter randomized clinical management trial
    exposure
    Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up
    limitations
    Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    The trial’s primary composite outcome was not statistically significant.
    primary_references
    [phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x
    tissue_or_cell_type
    339 critically ill adults developing refeeding syndrome within 72 hours of nutrition

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1154–1165

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Multicenter randomized clinical management trial · source_derived_draft · unverified_draft

    ### phosphorus-refeeding-primary Days alive after ICU discharge did not differ significantly: 44.8 versus 39.9 days, estimated difference 4.9 days (95% CI −2.3 to 13.6), p=0.19. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The trial’s primary composite outcome was not statistically significant. organism: Human tissue_or_cell_type: 339 critically ill adults developing refeeding syndrome within 72 hours of nutrition experimental_model: Multicenter randomized clinical management trial limitations: Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context. exposure: Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up evidence_span: {"source_cache": "artifacts/phosphorus-research/26597128.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6", "start_char": 0, "end_char": 2574, "text_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6"} [phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x
    Complete structured claim and evidence

  2. A component analysis found 149/164 participants alive at day 60 with restriction versus 128/163 with standard feeding, p=0.002.

    Protocolized caloric restriction during ICU refeeding-syndrome management → Day-60 survival in the ICU refeeding trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/phosphorus-research/26597128.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6", "start_char": 0, "end_char": 2574, "text_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6"}
    experimental_model
    Multicenter randomized clinical management trial
    exposure
    Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up
    limitations
    Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context.
    nutrient_topic
    Phosphorus research collection; topical membership is not evidence of a direct dietary effect. · Phosphorus
    organism
    Human
    plain_language
    The survival component favored the supervised strategy, while the primary composite remained nonsignificant.
    primary_references
    [phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x
    tissue_or_cell_type
    339 critically ill adults developing refeeding syndrome within 72 hours of nutrition

    Phosphorus: metabolism, signaling and nutrient connections (2026-09-17) · lines 1167–1178

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Multicenter randomized clinical management trial · source_derived_draft · unverified_draft

    ### phosphorus-refeeding-survival A component analysis found 149/164 participants alive at day 60 with restriction versus 128/163 with standard feeding, p=0.002. Condition category: normal nutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect. plain_language: The survival component favored the supervised strategy, while the primary composite remained nonsignificant. organism: Human tissue_or_cell_type: 339 critically ill adults developing refeeding syndrome within 72 hours of nutrition experimental_model: Multicenter randomized clinical management trial limitations: Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context. exposure: Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up evidence_span: {"source_cache": "artifacts/phosphorus-research/26597128.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6", "start_char": 0, "end_char": 2574, "text_sha256": "0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6"} [phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards