{"id":"fdd123f1-6264-59fc-aa6a-961a70799335","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-refeeding-survival","predicate":"improves_trial_component","statement":"A component analysis found 149/164 participants alive at day 60 with restriction versus 128/163 with standard feeding, p=0.002.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"96ef7cd7-0424-5a5c-9ddb-7b19bd6ec0b2","mechanism_event_label":"The survival component favored the supervised strategy, while the primary composite remained nonsignificant.","subject":{"id":"ab181ce0-24a4-571b-b533-1e4e04006ad4","slug":"refeeding-calorie-restriction","display_name":"Protocolized caloric restriction during ICU refeeding-syndrome management","entity_type_key":"cellular_process"},"object":{"id":"511e890f-b51c-552e-bbc8-cf14e967b79b","slug":"refeeding-day60-survival","display_name":"Day-60 survival in the ICU refeeding trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"96ef7cd7-0424-5a5c-9ddb-7b19bd6ec0b2","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-refeeding-survival-event","event_type":"observed_intervention","label":"The survival component favored the supervised strategy, while the primary composite remained nonsignificant.","description":"A component analysis found 149/164 participants alive at day 60 with restriction versus 128/163 with standard feeding, p=0.002.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ab181ce0-24a4-571b-b533-1e4e04006ad4","slug":"refeeding-calorie-restriction","display_name":"Protocolized caloric restriction during ICU refeeding-syndrome management","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"511e890f-b51c-552e-bbc8-cf14e967b79b","slug":"refeeding-day60-survival","display_name":"Day-60 survival in the ICU refeeding trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/26597128.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\", \"start_char\": 0, \"end_char\": 2574, \"text_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter randomized clinical management trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The survival component favored the supervised strategy, while the primary composite remained nonsignificant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"339 critically ill adults developing refeeding syndrome within 72 hours of nutrition","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4d83db33-e78b-5f11-8057-977fd6b1843c","evidence_kind":"source_excerpt","locator":"Lines 1167-1178","start_line":1167,"end_line":1178,"excerpt":"### phosphorus-refeeding-survival\nA component analysis found 149/164 participants alive at day 60 with restriction versus 128/163 with standard feeding, p=0.002.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The survival component favored the supervised strategy, while the primary composite remained nonsignificant.\norganism: Human\ntissue_or_cell_type: 339 critically ill adults developing refeeding syndrome within 72 hours of nutrition\nexperimental_model: Multicenter randomized clinical management trial\nlimitations: Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context.\nexposure: Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/26597128.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\", \"start_char\": 0, \"end_char\": 2574, \"text_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\"}\n[phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x","model_system":"Multicenter randomized clinical management trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. 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