{"id":"0612030a-dec5-56bc-ab0e-4d4c58549d7f","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-refeeding-primary","predicate":"has_no_significant_primary_effect","statement":"Days alive after ICU discharge did not differ significantly: 44.8 versus 39.9 days, estimated difference 4.9 days (95% CI −2.3 to 13.6), p=0.19.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"59b13742-1003-58b6-b2a9-ebb28993861e","mechanism_event_label":"The trial’s primary composite outcome was not statistically significant.","subject":{"id":"ab181ce0-24a4-571b-b533-1e4e04006ad4","slug":"refeeding-calorie-restriction","display_name":"Protocolized caloric restriction during ICU refeeding-syndrome management","entity_type_key":"cellular_process"},"object":{"id":"fdc4be19-c7f3-595b-aac1-9d3a656d5c0d","slug":"refeeding-days-alive-after-icu","display_name":"Days alive after ICU discharge over 60 days in the refeeding trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"59b13742-1003-58b6-b2a9-ebb28993861e","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-refeeding-primary-event","event_type":"observed_intervention","label":"The trial’s primary composite outcome was not statistically significant.","description":"Days alive after ICU discharge did not differ significantly: 44.8 versus 39.9 days, estimated difference 4.9 days (95% CI −2.3 to 13.6), p=0.19.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ab181ce0-24a4-571b-b533-1e4e04006ad4","slug":"refeeding-calorie-restriction","display_name":"Protocolized caloric restriction during ICU refeeding-syndrome management","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fdc4be19-c7f3-595b-aac1-9d3a656d5c0d","slug":"refeeding-days-alive-after-icu","display_name":"Days alive after ICU discharge over 60 days in the refeeding trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/26597128.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\", \"start_char\": 0, \"end_char\": 2574, \"text_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Multicenter randomized clinical management trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial’s primary composite outcome was not statistically significant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"339 critically ill adults developing refeeding syndrome within 72 hours of nutrition","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"39d22a94-3c18-5f9c-b89b-ea1cc333bb0a","evidence_kind":"source_excerpt","locator":"Lines 1154-1165","start_line":1154,"end_line":1165,"excerpt":"### phosphorus-refeeding-primary\nDays alive after ICU discharge did not differ significantly: 44.8 versus 39.9 days, estimated difference 4.9 days (95% CI −2.3 to 13.6), p=0.19.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial’s primary composite outcome was not statistically significant.\norganism: Human\ntissue_or_cell_type: 339 critically ill adults developing refeeding syndrome within 72 hours of nutrition\nexperimental_model: Multicenter randomized clinical management trial\nlimitations: Management-strategy trial, not isolated phosphate supplementation. Primary composite endpoint was nonsignificant; component results must retain that context.\nexposure: Protocolized caloric restriction versus continued standard feeding during electrolyte replacement; 60-day follow-up\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/26597128.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\", \"start_char\": 0, \"end_char\": 2574, \"text_sha256\": \"0324ddb02d92a61886682e682350e42356a4596c93e3ff60d23860163c6c1aa6\"}\n[phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/26597128/ DOI: 10.1016/s2213-2600(15)00418-x","model_system":"Multicenter randomized clinical management trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [phosphorus-p26597128] Restricted versus continued standard caloric intake during the management of refeeding syndrome in critically ill adults: a randomised, parallel-group, multicentre, single-blind controlled trial. 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