Component
Rod-expressed transgenic RDH10
Ectopic RDH10 expression in mouse rod photoreceptors; protein expression was mosaic.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Ectopic RDH10 expression did not enable bleached mouse rods to recover sensitivity when supplied with 9-cis-retinol.
Experimental context and source evidence
- cross_nutrient
- false
- evidence_location
- Figure 9C; Results: ectopic RDH10 expression
- experimental_model
- Rod RDH10 transgenesis; single-cell suction recordings
- exposure
- 100 micromolar 9-cis-retinol after approximately 50% pigment bleach.
- limitations
- Expression was mosaic; the substrate was 9-cis-retinol, not 11-cis-retinol. This tests sufficiency in rods, not necessity in cones.
- nutrient
- Vitamin A · Vitamin A
- nutrient_topic
- Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. · Vitamin A
- organism
- Mus musculus
- plain_language
- Adding RDH10 alone did not let rods use the supplied retinol isomer.
- primary_references
- [vav-xue2017] The role of retinol dehydrogenase 10 in the cone visual cycle. (2017). https://pubmed.ncbi.nlm.nih.gov/28539612/ DOI: 10.1038/s41598-017-02549-8
- tissue_or_cell_type
- isolated rods
Vitamin A expansion: reproduction, light-driven vision and shared mechanisms (2026-09-17) · lines 663–676
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Rod RDH10 transgenesis; single-cell suction recordings · source_derived_draft · unverified_draft
### vae-rdh10-rod-transgene-9cis-retinol Ectopic RDH10 expression did not enable bleached mouse rods to recover sensitivity when supplied with 9-cis-retinol. Condition category: normal nutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect. plain_language: Adding RDH10 alone did not let rods use the supplied retinol isomer. organism: Mus musculus tissue_or_cell_type: isolated rods experimental_model: Rod RDH10 transgenesis; single-cell suction recordings limitations: Expression was mosaic; the substrate was 9-cis-retinol, not 11-cis-retinol. This tests sufficiency in rods, not necessity in cones. exposure: 100 micromolar 9-cis-retinol after approximately 50% pigment bleach. cross_nutrient: false evidence_location: Figure 9C; Results: ectopic RDH10 expression nutrient: Vitamin A [vav-xue2017] The role of retinol dehydrogenase 10 in the cone visual cycle. (2017). https://pubmed.ncbi.nlm.nih.gov/28539612/ DOI: 10.1038/s41598-017-02549-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.