Component
Rat glucose-6-phosphate transporter / Slc37a4
Rat glucose-6-phosphate transporter / Slc37a4. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Parent chlorogenic acid inhibited the translocase component in intact rat liver microsomes.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/9003513.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f", "start_char": 0, "end_char": 1355, "text_sha256": "995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f"}
- experimental_model
- Microsomal inhibition and isolated perfused-liver experiments
- exposure
- Parent CGA and synthesized derivatives; compound 29i in organ experiment
- limitations
- The parent and more potent lipophilic derivatives are different chemicals. Reduced G6P hydrolysis in intact microsomes implicates substrate transport, not necessarily direct inhibition of the catalytic phosphatase.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Rat
- plain_language
- The transport step can limit delivery to the glucose-releasing enzyme.
- primary_references
- [chlorogenic_acid-p9003513] Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. (1997). https://pubmed.ncbi.nlm.nih.gov/9003513/ DOI: 10.1021/jm9607360
- tissue_or_cell_type
- Hepatic microsomes and perfused liver
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 386–397
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Microsomal inhibition and isolated perfused-liver experiments · source_derived_draft · unverified_draft
### chlorogenic_acid-rat-translocase Parent chlorogenic acid inhibited the translocase component in intact rat liver microsomes. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The transport step can limit delivery to the glucose-releasing enzyme. organism: Rat tissue_or_cell_type: Hepatic microsomes and perfused liver experimental_model: Microsomal inhibition and isolated perfused-liver experiments limitations: The parent and more potent lipophilic derivatives are different chemicals. Reduced G6P hydrolysis in intact microsomes implicates substrate transport, not necessarily direct inhibition of the catalytic phosphatase. exposure: Parent CGA and synthesized derivatives; compound 29i in organ experiment evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/9003513.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f", "start_char": 0, "end_char": 1355, "text_sha256": "995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f"} [chlorogenic_acid-p9003513] Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. (1997). https://pubmed.ncbi.nlm.nih.gov/9003513/ DOI: 10.1021/jm9607360
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.