{"id":"8b05158e-5bae-5f46-8dd2-174875dc40d7","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-rat-translocase","predicate":"inhibits","statement":"Parent chlorogenic acid inhibited the translocase component in intact rat liver microsomes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"44feb22c-3524-59b1-87e2-eaa195ce9111","mechanism_event_label":"The transport step can limit delivery to the glucose-releasing enzyme.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"4be0a9be-760c-5137-a975-202a1dd9158b","slug":"rat-slc37a4","display_name":"Rat glucose-6-phosphate transporter / Slc37a4","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"44feb22c-3524-59b1-87e2-eaa195ce9111","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-rat-translocase-event","event_type":"biochemical_relationship","label":"The transport step can limit delivery to the glucose-releasing enzyme.","description":"Parent chlorogenic acid inhibited the translocase component in intact rat liver microsomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4be0a9be-760c-5137-a975-202a1dd9158b","slug":"rat-slc37a4","display_name":"Rat glucose-6-phosphate transporter / Slc37a4","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/9003513.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f\", \"start_char\": 0, \"end_char\": 1355, \"text_sha256\": \"995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Microsomal inhibition and isolated perfused-liver experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Parent CGA and synthesized derivatives; compound 29i in organ experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The parent and more potent lipophilic derivatives are different chemicals. Reduced G6P hydrolysis in intact microsomes implicates substrate transport, not necessarily direct inhibition of the catalytic phosphatase.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The transport step can limit delivery to the glucose-releasing enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p9003513] Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. (1997). https://pubmed.ncbi.nlm.nih.gov/9003513/ DOI: 10.1021/jm9607360","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Hepatic microsomes and perfused liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"29bfc47e-4eee-58e0-8ec8-57cff0f0b8ca","evidence_kind":"source_excerpt","locator":"Lines 386-397","start_line":386,"end_line":397,"excerpt":"### chlorogenic_acid-rat-translocase\nParent chlorogenic acid inhibited the translocase component in intact rat liver microsomes.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The transport step can limit delivery to the glucose-releasing enzyme.\norganism: Rat\ntissue_or_cell_type: Hepatic microsomes and perfused liver\nexperimental_model: Microsomal inhibition and isolated perfused-liver experiments\nlimitations: The parent and more potent lipophilic derivatives are different chemicals. Reduced G6P hydrolysis in intact microsomes implicates substrate transport, not necessarily direct inhibition of the catalytic phosphatase.\nexposure: Parent CGA and synthesized derivatives; compound 29i in organ experiment\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/9003513.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f\", \"start_char\": 0, \"end_char\": 1355, \"text_sha256\": \"995b8001c0461fc38f9d57e9fdb83d334165176bc4df75083315c8f21ca8f90f\"}\n[chlorogenic_acid-p9003513] Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. (1997). https://pubmed.ncbi.nlm.nih.gov/9003513/ DOI: 10.1021/jm9607360","model_system":"Microsomal inhibition and isolated perfused-liver experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p9003513] Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. (1997). https://pubmed.ncbi.nlm.nih.gov/9003513/ DOI: 10.1021/jm9607360","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"98a7cb8d-1d80-5cfe-9690-4068d21878e3","stable_key":"import-00c24cfe-6189-5244-b81f-5d693e4e177d","title":"Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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