Component
Histamine release from rat peritoneal mast cells
Experimental model, exposure and limitations remain on each linked record.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Tartrazine at 0.1-1 mM augmented A23187-triggered histamine release in the rat mast-cell assay.
Experimental context and source evidence
- dose
- Tartrazine 0.1-1 mM with calcium ionophore A23187
- duration
- Maximum augmentation with 0-5 min preincubation
- evidence_access
- Primary PubMed abstract; unrecovered method details explicitly retained.
- evidence_scope
- literature_reviewed; source-specific experimental curation
- experimental_model
- Purified rat peritoneal mast cells
- limitations
- The ionophore interaction cannot be generalized to every mast-cell stimulus; higher concentrations had a small inhibitory effect.
- nutrient_topic
- Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
- organism
- Purified rat peritoneal mast cells
- plain_language
- Tartrazine at 0.1-1 mM augmented A23187-triggered histamine release in the rat mast-cell assay.
- primary_references
- The effect of tartrazine on histamine release from rat peritoneal mast cells. (1984). https://pubmed.ncbi.nlm.nih.gov/6204951/ DOI: 10.1016/0192-0561(84)90021-3
- route
- In vitro preincubation and challenge
- tissue
- Calcium-ionophore-triggered histamine release
Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 468–477
Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Purified rat peritoneal mast cells · source_derived_draft · unverified_draft
## tartrazine-mast-cell-augmentation Tartrazine at 0.1-1 mM augmented A23187-triggered histamine release in the rat mast-cell assay. Model/species: Purified rat peritoneal mast cells Tissue: Calcium-ionophore-triggered histamine release Exposure: Tartrazine 0.1-1 mM with calcium ionophore A23187 Route: In vitro preincubation and challenge Duration: Maximum augmentation with 0-5 min preincubation Limits: The ionophore interaction cannot be generalized to every mast-cell stimulus; higher concentrations had a small inhibitory effect. Primary reference: The effect of tartrazine on histamine release from rat peritoneal mast cells. (1984). https://pubmed.ncbi.nlm.nih.gov/6204951/ DOI: 10.1016/0192-0561(84)90021-3 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
Complete structured claim and evidenceTartrazine inhibited compound-48/80- and antigen-triggered histamine release from rat peritoneal mast cells.
Experimental context and source evidence
- dose
- Tartrazine 10 micromolar-10 mM with compound 48/80 or egg-albumin challenge
- duration
- Acute release assay; antigen inhibition strongest with simultaneous addition
- evidence_access
- Primary PubMed abstract; unrecovered method details explicitly retained.
- evidence_scope
- literature_reviewed; source-specific experimental curation
- experimental_model
- Purified rat peritoneal mast cells
- limitations
- Secretagogue and timing alter the response. This is not a demonstration of spontaneous histamine release or a human allergic mechanism.
- nutrient_topic
- Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits. · Tartrazine
- organism
- Purified rat peritoneal mast cells
- plain_language
- Tartrazine inhibited compound-48/80- and antigen-triggered histamine release from rat peritoneal mast cells.
- primary_references
- The effect of tartrazine on histamine release from rat peritoneal mast cells. (1984). https://pubmed.ncbi.nlm.nih.gov/6204951/ DOI: 10.1016/0192-0561(84)90021-3
- route
- In vitro co-exposure
- tissue
- Secretagogue-induced histamine release
Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 457–466
Original AI-assisted curation of eighteen primary studies. Study-specific citations, negative findings and limitations retained. Not publisher full text. · supports · Purified rat peritoneal mast cells · source_derived_draft · unverified_draft
## tartrazine-mast-cell-inhibition Tartrazine inhibited compound-48/80- and antigen-triggered histamine release from rat peritoneal mast cells. Model/species: Purified rat peritoneal mast cells Tissue: Secretagogue-induced histamine release Exposure: Tartrazine 10 micromolar-10 mM with compound 48/80 or egg-albumin challenge Route: In vitro co-exposure Duration: Acute release assay; antigen inhibition strongest with simultaneous addition Limits: Secretagogue and timing alter the response. This is not a demonstration of spontaneous histamine release or a human allergic mechanism. Primary reference: The effect of tartrazine on histamine release from rat peritoneal mast cells. (1984). https://pubmed.ncbi.nlm.nih.gov/6204951/ DOI: 10.1016/0192-0561(84)90021-3 Access: Primary PubMed abstract; unrecovered method details explicitly retained.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.