Component

Rat epidermal growth factor

Rat renal EGF, the signal that raises TRPM6 in this model.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Epidermal growth factor did not raise TRPM6 or lower the fractional excretion of magnesium in cyclosporine-treated rats, although it did both in controls.

    Rat epidermal growth factor → Rat TRPM6 source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    duration
    Not stated here
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    Cyclosporine-treated rats compared with controls
    exposure
    Epidermal growth factor administration during cyclosporine treatment
    limitations
    A measured null in the treated arm. It says the EGF route is not simply underfilled during cyclosporine exposure, and it does not say where the block sits.
    organism
    Cyclosporine-treated rats compared with controls
    plain_language
    Epidermal growth factor did not raise TRPM6 or lower the fractional excretion of magnesium in cyclosporine-treated rats, although it did both in controls.
    primary_references
    Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment. (2011). https://pubmed.ncbi.nlm.nih.gov/21653632/ DOI: 10.1152/ajprenal.00116.2011
    route
    In vivo
    tissue
    Distal convoluted tubule
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23) · lines 267–267

    Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text. · supports · Cyclosporine-treated rats compared with controls · source_derived_draft · unverified_draft

    Epidermal growth factor did not raise TRPM6 or lower the fractional excretion of magnesium in cyclosporine-treated rats, although it did both in controls.
    Complete structured claim and evidence

  2. In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.

    Rat epidermal growth factor → Rat TRPM6 source_derived_draftungraded
    Experimental context and source evidence
    duration
    Not stated here
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    Control rats
    exposure
    Epidermal growth factor administration
    limitations
    Measured in control animals, which establishes the route without establishing that it is the route cyclosporine breaks.
    organism
    Control rats
    plain_language
    In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.
    primary_references
    Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment. (2011). https://pubmed.ncbi.nlm.nih.gov/21653632/ DOI: 10.1152/ajprenal.00116.2011
    route
    In vivo
    tissue
    Distal convoluted tubule

    Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23) · lines 256–256

    Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text. · supports · Control rats · source_derived_draft · unverified_draft

    In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.
    Complete structured claim and evidence

What acts on it

  1. Cyclosporine significantly decreased renal expression of epidermal growth factor in the same rat model.

    Cyclosporine → Rat epidermal growth factor source_derived_draftungraded
    Experimental context and source evidence
    duration
    Not stated here
    evidence_access
    Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.
    experimental_model
    Rat model of cyclosporine nephrotoxicity
    exposure
    Cyclosporine, dose and duration not stated here
    limitations
    This is the step that makes the magnesium loss a signalling failure rather than direct channel blockade, but the abstract reports the two falls together without demonstrating that one causes the other in this model.
    organism
    Rat model of cyclosporine nephrotoxicity
    plain_language
    Cyclosporine significantly decreased renal expression of epidermal growth factor in the same rat model.
    primary_references
    Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment. (2011). https://pubmed.ncbi.nlm.nih.gov/21653632/ DOI: 10.1152/ajprenal.00116.2011
    route
    In vivo
    tissue
    Kidney

    Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23) · lines 245–245

    Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text. · supports · Rat model of cyclosporine nephrotoxicity · source_derived_draft · unverified_draft

    Cyclosporine significantly decreased renal expression of epidermal growth factor in the same rat model.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards