{"id":"c68d5606-271f-5ca0-9f6f-6a1a528001fe","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:egf-raises-renal-trpm6","predicate":"increases_expression_of","statement":"In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"2403509d-9cc3-50ff-b750-8ad515d21e92","mechanism_event_label":"In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.","subject":{"id":"5b7b2ef5-f340-5555-af19-fe13a433a0e2","slug":"rat-egf","display_name":"Rat epidermal growth factor","entity_type_key":"protein"},"object":{"id":"d73ae2fe-873a-55df-ac69-ee16eea54bd4","slug":"rat-trpm6","display_name":"Rat TRPM6","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"2403509d-9cc3-50ff-b750-8ad515d21e92","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:egf-raises-renal-trpm6-event","event_type":"observed_intervention","label":"In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.","description":"Distal convoluted tubule","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5b7b2ef5-f340-5555-af19-fe13a433a0e2","slug":"rat-egf","display_name":"Rat epidermal growth factor","entity_type_key":"protein"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d73ae2fe-873a-55df-ac69-ee16eea54bd4","slug":"rat-trpm6","display_name":"Rat TRPM6","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Control rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Epidermal growth factor administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measured in control animals, which establishes the route without establishing that it is the route cyclosporine breaks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Control rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Expression of renal distal tubule transporters TRPM6 and NCC in a rat model of cyclosporine nephrotoxicity and effect of EGF treatment. (2011). https://pubmed.ncbi.nlm.nih.gov/21653632/ DOI: 10.1152/ajprenal.00116.2011","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Distal convoluted tubule","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7f87f70d-66a9-5f59-bb3a-f1c9f94f2aaa","evidence_kind":"source_excerpt","locator":"Lines 256-256","start_line":256,"end_line":256,"excerpt":"In control rats given epidermal growth factor, renal TRPM6 expression rose and the fractional excretion of magnesium fell.","model_system":"Control rats","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"6b2b7746-fc66-5491-b896-e6261df254c9","stable_key":"import-1bbf9d44-8d2b-5b35-8f82-f6876558b0b3","title":"Cyclosporine: the complex that inhibits calcineurin, a second cyclophilin, and the transport step that decides exposure (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation of seven primary studies resolved by PubMed title search, with every abstract read and all DOIs cross-checked against live PubMed metadata on 2026-09-23. No reference carries a recorded retraction, erratum or expression of concern. Each of the seven is a separate laboratory and each carries its own lineage key, so none of them can be counted twice as independent support. Study-specific concentrations, kinetic constants and limitations retained. Not publisher full text.","file_path":"","sha256":"499d00555a629cba2271c3888d7e93627949891d565c4c78c843610de2913080","revision_id":"263ee68a-4184-51d0-a977-197d7ddb7a4d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}