{"id":"a81463cc-6670-5e88-833b-a2d66bacaa88","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-renal-egf","predicate":"reduces_expression_of","statement":"Cyclosporine significantly decreased renal expression of epidermal growth factor in the same rat model.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"1617e94b-7174-53f3-9f72-cf7a54c8cb6e","mechanism_event_label":"Cyclosporine significantly decreased renal expression of epidermal growth factor in the same rat model.","subject":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"object":{"id":"5b7b2ef5-f340-5555-af19-fe13a433a0e2","slug":"rat-egf","display_name":"Rat epidermal growth factor","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"1617e94b-7174-53f3-9f72-cf7a54c8cb6e","stable_key":"1bbf9d44-8d2b-5b35-8f82-f6876558b0b3:cyclosporine-lowers-renal-egf-event","event_type":"observed_intervention","label":"Cyclosporine significantly decreased renal expression of epidermal growth factor in the same rat model.","description":"Kidney","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b199063a-fae6-5c5c-9cb4-22c10453bbac","slug":"cyclosporine","display_name":"Cyclosporine","entity_type_key":"drug"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5b7b2ef5-f340-5555-af19-fe13a433a0e2","slug":"rat-egf","display_name":"Rat epidermal growth factor","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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