Component
Rat D-aspartate oxidase / Ddo
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Rat kidney, liver and brain DDO activity became detectable one to four days after birth and reached adult values around four weeks.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Rat tissue oxidase assays; activity greatest in kidney in the tested panel.
- limitations
- No equivalent human developmental timetable or adult dietary requirement is established.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- The breakdown system changes during development.
- primary_references
- D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1991137/ · DOI 10.1016/0304-4165(91)90203-s
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 136–142
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Rat tissue oxidase assays; activity greatest in kidney in the tested panel. · source_derived_draft · unverified_draft
## d-aspartate-ddo-development The breakdown system changes during development. Rat kidney, liver and brain DDO activity became detectable one to four days after birth and reached adult values around four weeks. Model: Rat tissue oxidase assays; activity greatest in kidney in the tested panel. Limitations: No equivalent human developmental timetable or adult dietary requirement is established. Evidence access: Primary abstract D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1991137/ · DOI 10.1016/0304-4165(91)90203-s
Complete structured claim and evidence
Where it participates (unsigned role)
Purified human, rat and mouse DDO differed in kinetic and inhibitor-binding properties.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Comparative recombinant enzyme assays and structural models.
- limitations
- Rodent efficacy is not a measured human effect.
- nutrient_topic
- D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · D-Aspartate
- plain_language
- A compound that changes rodent clearance may act differently on the human enzyme.
- primary_references
- Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25747990/ · DOI 10.1248/bpb.b14-00690
D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19) · lines 128–134
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Comparative recombinant enzyme assays and structural models. · source_derived_draft · unverified_draft
## d-aspartate-ddo-species A compound that changes rodent clearance may act differently on the human enzyme. Purified human, rat and mouse DDO differed in kinetic and inhibitor-binding properties. Model: Comparative recombinant enzyme assays and structural models. Limitations: Rodent efficacy is not a measured human effect. Evidence access: Primary abstract Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25747990/ · DOI 10.1248/bpb.b14-00690
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.