{"id":"dfeddf45-6343-5a74-b682-0a6e42a29d96","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ddo-development","predicate":"increases_during","statement":"Rat kidney, liver and brain DDO activity became detectable one to four days after birth and reached adult values around four weeks.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"abacca07-adff-5ea2-8146-5f043dfab8cf","mechanism_event_label":"The breakdown system changes during development.","subject":{"id":"56a1f2a6-f36d-5a30-ab7e-0106f37120b2","slug":"rat-ddo","display_name":"Rat D-aspartate oxidase / Ddo","entity_type_key":"protein"},"object":{"id":"d806e5d8-875e-5b1d-99f6-3d620749b04a","slug":"rat-postnatal-ddo-activity","display_name":"Postnatal DDO activity in rat tissues","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"abacca07-adff-5ea2-8146-5f043dfab8cf","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ddo-development-event","event_type":"observed_relationship","label":"The breakdown system changes during development.","description":"Rat kidney, liver and brain DDO activity became detectable one to four days after birth and reached adult values around four weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"56a1f2a6-f36d-5a30-ab7e-0106f37120b2","slug":"rat-ddo","display_name":"Rat D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d806e5d8-875e-5b1d-99f6-3d620749b04a","slug":"rat-postnatal-ddo-activity","display_name":"Postnatal DDO activity in rat tissues","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat tissue oxidase assays; activity greatest in kidney in the tested panel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No equivalent human developmental timetable or adult dietary requirement is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The breakdown system changes during development.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1991137/ · DOI 10.1016/0304-4165(91)90203-s","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"725aba79-745a-514e-a99b-8d2a3b738813","evidence_kind":"source_excerpt","locator":"Lines 136-142","start_line":136,"end_line":142,"excerpt":"## d-aspartate-ddo-development\nThe breakdown system changes during development.\nRat kidney, liver and brain DDO activity became detectable one to four days after birth and reached adult values around four weeks.\nModel: Rat tissue oxidase assays; activity greatest in kidney in the tested panel.\nLimitations: No equivalent human developmental timetable or adult dietary requirement is established.\nEvidence access: Primary abstract\nD-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1991137/ · DOI 10.1016/0304-4165(91)90203-s","model_system":"Rat tissue oxidase assays; activity greatest in kidney in the tested panel.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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