{"id":"5ecce34a-6431-5be7-9272-7bbb848b5278","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ddo-species","predicate":"differs_in_kinetics_from","statement":"Purified human, rat and mouse DDO differed in kinetic and inhibitor-binding properties.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"861e3352-5f5b-5795-b383-1609fa11e550","mechanism_event_label":"A compound that changes rodent clearance may act differently on the human enzyme.","subject":{"id":"17871951-099f-5a48-832e-ff9cb1c65755","slug":"ddo","display_name":"Human D-aspartate oxidase / DDO","entity_type_key":"protein"},"object":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"861e3352-5f5b-5795-b383-1609fa11e550","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-ddo-species-event","event_type":"observed_relationship","label":"A compound that changes rodent clearance may act differently on the human enzyme.","description":"Purified human, rat and mouse DDO differed in kinetic and inhibitor-binding properties.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"17871951-099f-5a48-832e-ff9cb1c65755","slug":"ddo","display_name":"Human D-aspartate oxidase / DDO","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f3fc3b2e-7748-5a0a-a936-94c47f68a6d2","slug":"mouse-ddo","display_name":"Mouse D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"56a1f2a6-f36d-5a30-ab7e-0106f37120b2","slug":"rat-ddo","display_name":"Rat D-aspartate oxidase / Ddo","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Comparative recombinant enzyme assays and structural models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rodent efficacy is not a measured human effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A compound that changes rodent clearance may act differently on the human enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25747990/ · DOI 10.1248/bpb.b14-00690","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"44bf9834-f9e1-59d0-84c7-73c46ca81044","evidence_kind":"source_excerpt","locator":"Lines 128-134","start_line":128,"end_line":134,"excerpt":"## d-aspartate-ddo-species\nA compound that changes rodent clearance may act differently on the human enzyme.\nPurified human, rat and mouse DDO differed in kinetic and inhibitor-binding properties.\nModel: Comparative recombinant enzyme assays and structural models.\nLimitations: Rodent efficacy is not a measured human effect.\nEvidence access: Primary abstract\nCharacterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25747990/ · DOI 10.1248/bpb.b14-00690","model_system":"Comparative recombinant enzyme assays and structural models.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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