Rat cannabinoid receptor 1 / Cnr1: molecular mechanisms & dependencies

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

Human evidence only

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

The authors linked CB1 antagonism to ERK-dependent regulation of glutamine synthetase in rats, with different ERK responses in normal and stressed conditions.
Rat cannabinoid receptor 1 / Cnr1 → Rat glutamine synthetase / Glul source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/34037653.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1", "start_char": 0, "end_char": 1786, "text_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1"}
experimental_model
Receptor interaction and pathway assays
exposure
Theanine; normal versus experimental stress conditions
limitations
Preclinical CB1-binding claim requires independent confirmation at human exposures; signaling direction differed between normal and stressed rats. No equivalence to cannabinoid drugs inferred.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
Normal and E44813-stressed rats
plain_language
Receptor signaling connects to the enzyme that makes glutamine; the direction depends on context.
primary_references
[theanine-p34037653] L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1. (2021). https://pubmed.ncbi.nlm.nih.gov/34037653/ DOI: 10.1039/d1fo00505g
tissue_or_cell_type
CB1-associated immune and glutamine regulation
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 484–495
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor interaction and pathway assays · source_derived_draft · unverified_draft
### theanine-cb1-gs The authors linked CB1 antagonism to ERK-dependent regulation of glutamine synthetase in rats, with different ERK responses in normal and stressed conditions. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: Receptor signaling connects to the enzyme that makes glutamine; the direction depends on context. organism: Normal and E44813-stressed rats tissue_or_cell_type: CB1-associated immune and glutamine regulation experimental_model: Receptor interaction and pathway assays limitations: Preclinical CB1-binding claim requires independent confirmation at human exposures; signaling direction differed between normal and stressed rats. No equivalence to cannabinoid drugs inferred. exposure: Theanine; normal versus experimental stress conditions evidence_span: {"source_cache": "artifacts/theanine-research/34037653.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1", "start_char": 0, "end_char": 1786, "text_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1"} [theanine-p34037653] L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1. (2021). https://pubmed.ncbi.nlm.nih.gov/34037653/ DOI: 10.1039/d1fo00505g
Complete structured claim and evidence

What acts on it

The study reported competitive binding and inhibition of rat cannabinoid receptor 1 by theanine.
L-Theanine → Rat cannabinoid receptor 1 / Cnr1 source_derived_draftungraded
Experimental context and source evidence
evidence_span
{"source_cache": "artifacts/theanine-research/34037653.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1", "start_char": 0, "end_char": 1786, "text_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1"}
experimental_model
Receptor interaction and pathway assays
exposure
Theanine; normal versus experimental stress conditions
limitations
Preclinical CB1-binding claim requires independent confirmation at human exposures; signaling direction differed between normal and stressed rats. No equivalence to cannabinoid drugs inferred.
nutrient_topic
L-Theanine research collection; topical membership is not evidence of a direct dietary effect. · L-Theanine
organism
Normal and E44813-stressed rats
plain_language
A proposed receptor connection is preserved with its rat-model limits.
primary_references
[theanine-p34037653] L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1. (2021). https://pubmed.ncbi.nlm.nih.gov/34037653/ DOI: 10.1039/d1fo00505g
tissue_or_cell_type
CB1-associated immune and glutamine regulation
L-Theanine: metabolism, neural signaling, nutrient connections and human outcomes (2026-09-17) · lines 471–482
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Receptor interaction and pathway assays · source_derived_draft · unverified_draft
### theanine-cb1 The study reported competitive binding and inhibition of rat cannabinoid receptor 1 by theanine. Condition category: normal nutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect. plain_language: A proposed receptor connection is preserved with its rat-model limits. organism: Normal and E44813-stressed rats tissue_or_cell_type: CB1-associated immune and glutamine regulation experimental_model: Receptor interaction and pathway assays limitations: Preclinical CB1-binding claim requires independent confirmation at human exposures; signaling direction differed between normal and stressed rats. No equivalence to cannabinoid drugs inferred. exposure: Theanine; normal versus experimental stress conditions evidence_span: {"source_cache": "artifacts/theanine-research/34037653.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1", "start_char": 0, "end_char": 1786, "text_sha256": "c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1"} [theanine-p34037653] L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1. (2021). https://pubmed.ncbi.nlm.nih.gov/34037653/ DOI: 10.1039/d1fo00505g
Complete structured claim and evidence

The events it takes part in

A mechanism often involves more than two components. These are the full events, with every participant and its role.

Situations it appears in

Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

Open hypotheses

Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.

This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

Rat cannabinoid receptor 1 / Cnr1