{"id":"9860f54a-cae1-53a2-b17b-820ecb370b54","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-cb1","predicate":"reported_competitive_binding_and_inhibition_of","statement":"The study reported competitive binding and inhibition of rat cannabinoid receptor 1 by theanine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"73b0f8c0-4846-53ba-b9d1-5d8c2cbf716c","mechanism_event_label":"A proposed receptor connection is preserved with its rat-model limits.","subject":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"object":{"id":"393f3047-98bf-5974-ad23-a5520c63b2b2","slug":"rat-cnr1","display_name":"Rat cannabinoid receptor 1 / Cnr1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"73b0f8c0-4846-53ba-b9d1-5d8c2cbf716c","stable_key":"8f12ba85-1a92-5337-a9c0-9cee9b3be90d:theanine-cb1-event","event_type":"biochemical_relationship","label":"A proposed receptor connection is preserved with its rat-model limits.","description":"The study reported competitive binding and inhibition of rat cannabinoid receptor 1 by theanine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"33a051c5-dba8-53cd-8761-c53732c447e6","slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"393f3047-98bf-5974-ad23-a5520c63b2b2","slug":"rat-cnr1","display_name":"Rat cannabinoid receptor 1 / Cnr1","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/theanine-research/34037653.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1\", \"start_char\": 0, \"end_char\": 1786, \"text_sha256\": \"c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Receptor interaction and pathway assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Theanine; normal versus experimental stress conditions","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical CB1-binding claim requires independent confirmation at human exposures; signaling direction differed between normal and stressed rats. 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No equivalence to cannabinoid drugs inferred.\nexposure: Theanine; normal versus experimental stress conditions\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/34037653.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1\", \"start_char\": 0, \"end_char\": 1786, \"text_sha256\": \"c792377afacbf5a17e93e4675a4a28ee6849d0288bfc09ad53a2377a0bb982b1\"}\n[theanine-p34037653] L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1. (2021). https://pubmed.ncbi.nlm.nih.gov/34037653/ DOI: 10.1039/d1fo00505g","model_system":"Receptor interaction and pathway assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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