Component
Rat renal proximal-tubule ATP during citrinin exposure
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Citrinin exposure reduced ATP in rat proximal-tubule suspensions before or during ensuing cell injury.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- 125–500 micromolar citrinin; reported ATP declines 22–48% at selected 0.5–1.5 hour time points.
- limitations
- Not a measured amount ingested from red yeast rice; lower exposures and human relevance require separate data.
- nutrient_topic
- Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
- plain_language
- Energy loss was measured in the kidney-cell preparation.
- primary_references
- [1853344] The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1853344/ · DOI 10.1016/0041-008x(91)90008-3
Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 316–322
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 125–500 micromolar citrinin; reported ATP declines 22–48% at selected 0.5–1.5 hour time points. · source_derived_draft · unverified_draft
## red-yeast-rice-citrinin-atp Energy loss was measured in the kidney-cell preparation. Citrinin exposure reduced ATP in rat proximal-tubule suspensions before or during ensuing cell injury. Model: 125–500 micromolar citrinin; reported ATP declines 22–48% at selected 0.5–1.5 hour time points. Limitations: Not a measured amount ingested from red yeast rice; lower exposures and human relevance require separate data. Evidence access: Primary abstract [1853344] The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1853344/ · DOI 10.1016/0041-008x(91)90008-3
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.