{"id":"4f385f0a-b027-5bf2-832b-70b8d7cf6bcd","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-citrinin-atp","predicate":"reduces_tested","statement":"Citrinin exposure reduced ATP in rat proximal-tubule suspensions before or during ensuing cell injury.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"528e71f9-ed14-5be3-884d-e416057a9709","mechanism_event_label":"Energy loss was measured in the kidney-cell preparation.","subject":{"id":"41817c29-526e-5b62-8db3-9553d316ea84","slug":"citrinin","display_name":"Citrinin","entity_type_key":"small_molecule"},"object":{"id":"fff8d7ff-7f20-58d5-a6a5-88d1d9cb8d8d","slug":"rat-citrinin-proximal-tubule-atp","display_name":"Rat renal proximal-tubule ATP during citrinin exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"528e71f9-ed14-5be3-884d-e416057a9709","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-citrinin-atp-event","event_type":"observed_relationship","label":"Energy loss was measured in the kidney-cell preparation.","description":"Citrinin exposure reduced ATP in rat proximal-tubule suspensions before or during ensuing cell injury.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"41817c29-526e-5b62-8db3-9553d316ea84","slug":"citrinin","display_name":"Citrinin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fff8d7ff-7f20-58d5-a6a5-88d1d9cb8d8d","slug":"rat-citrinin-proximal-tubule-atp","display_name":"Rat renal proximal-tubule ATP during citrinin exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"125–500 micromolar citrinin; reported ATP declines 22–48% at selected 0.5–1.5 hour time points.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a measured amount ingested from red yeast rice; lower exposures and human relevance require separate data.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Energy loss was measured in the kidney-cell preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[1853344] The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1853344/ · DOI 10.1016/0041-008x(91)90008-3","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"91354e29-af26-5b8b-b669-8361d058df86","evidence_kind":"source_excerpt","locator":"Lines 316-322","start_line":316,"end_line":322,"excerpt":"## red-yeast-rice-citrinin-atp\nEnergy loss was measured in the kidney-cell preparation.\nCitrinin exposure reduced ATP in rat proximal-tubule suspensions before or during ensuing cell injury.\nModel: 125–500 micromolar citrinin; reported ATP declines 22–48% at selected 0.5–1.5 hour time points.\nLimitations: Not a measured amount ingested from red yeast rice; lower exposures and human relevance require separate data.\nEvidence access: Primary abstract\n[1853344] The role of altered mitochondrial function in citrinin-induced toxicity to rat renal proximal tubule suspensions. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1853344/ · DOI 10.1016/0041-008x(91)90008-3","model_system":"125–500 micromolar citrinin; reported ATP declines 22–48% at selected 0.5–1.5 hour time points.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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