Component
Rat renal cortical mitochondrial phosphorylation efficiency
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Citrinin lowered respiratory control, ADP/O ratio and membrane potential in rat renal cortical mitochondria.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Isolated rat mitochondria; the enzyme-panel experiments included 1 mM citrinin.
- limitations
- Multiple effects were reported; this is not a selective single-complex inhibitor or a human exposure threshold.
- nutrient_topic
- Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
- plain_language
- Mitochondrial oxygen use and ATP production became less efficiently coupled.
- primary_references
- [1556379] Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1556379/ · DOI 10.1002/jat.2550120209
Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 332–338
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Isolated rat mitochondria; the enzyme-panel experiments included 1 mM citrinin. · source_derived_draft · unverified_draft
## red-yeast-rice-citrinin-coupling Mitochondrial oxygen use and ATP production became less efficiently coupled. Citrinin lowered respiratory control, ADP/O ratio and membrane potential in rat renal cortical mitochondria. Model: Isolated rat mitochondria; the enzyme-panel experiments included 1 mM citrinin. Limitations: Multiple effects were reported; this is not a selective single-complex inhibitor or a human exposure threshold. Evidence access: Primary abstract [1556379] Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1556379/ · DOI 10.1002/jat.2550120209
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.