{"id":"1e703766-a190-5e58-83be-365baddeb940","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-citrinin-coupling","predicate":"reduces_tested","statement":"Citrinin lowered respiratory control, ADP/O ratio and membrane potential in rat renal cortical mitochondria.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"84a1ca7a-1cac-515f-9bf9-e2336cfc073b","mechanism_event_label":"Mitochondrial oxygen use and ATP production became less efficiently coupled.","subject":{"id":"41817c29-526e-5b62-8db3-9553d316ea84","slug":"citrinin","display_name":"Citrinin","entity_type_key":"small_molecule"},"object":{"id":"b2d8cb35-5bcf-5f76-864c-c4df5d6dabce","slug":"rat-citrinin-mitochondrial-phosphorylation","display_name":"Rat renal cortical mitochondrial phosphorylation efficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"84a1ca7a-1cac-515f-9bf9-e2336cfc073b","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-citrinin-coupling-event","event_type":"observed_relationship","label":"Mitochondrial oxygen use and ATP production became less efficiently coupled.","description":"Citrinin lowered respiratory control, ADP/O ratio and membrane potential in rat renal cortical mitochondria.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"41817c29-526e-5b62-8db3-9553d316ea84","slug":"citrinin","display_name":"Citrinin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b2d8cb35-5bcf-5f76-864c-c4df5d6dabce","slug":"rat-citrinin-mitochondrial-phosphorylation","display_name":"Rat renal cortical mitochondrial phosphorylation efficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"58b974f1-d389-5bf6-81cd-889c44442c42","slug":"atp","display_name":"ATP","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated rat mitochondria; the enzyme-panel experiments included 1 mM citrinin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Multiple effects were reported; this is not a selective single-complex inhibitor or a human exposure threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Mitochondrial oxygen use and ATP production became less efficiently coupled.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[1556379] Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1556379/ · DOI 10.1002/jat.2550120209","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e34a411a-edeb-5e38-8e53-6aff00a1a18c","evidence_kind":"source_excerpt","locator":"Lines 332-338","start_line":332,"end_line":338,"excerpt":"## red-yeast-rice-citrinin-coupling\nMitochondrial oxygen use and ATP production became less efficiently coupled.\nCitrinin lowered respiratory control, ADP/O ratio and membrane potential in rat renal cortical mitochondria.\nModel: Isolated rat mitochondria; the enzyme-panel experiments included 1 mM citrinin.\nLimitations: Multiple effects were reported; this is not a selective single-complex inhibitor or a human exposure threshold.\nEvidence access: Primary abstract\n[1556379] Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria. · 1992 · https://pubmed.ncbi.nlm.nih.gov/1556379/ · DOI 10.1002/jat.2550120209","model_system":"Isolated rat mitochondria; the enzyme-panel experiments included 1 mM citrinin.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"261a12bc-3d00-52a4-a5ec-70e174390596","stable_key":"import-4910e17b-aaec-52cd-b9e5-caca85d817ee","title":"Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"271bbcecaaacc76ad4d06718ae592dc6a1b33e3e459adfdd36cbd0ac5f09c0f6","revision_id":"9c30956c-206c-5c49-ae42-81b070088e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}