Component
Rat calcium/calmodulin-dependent protein kinase kinase family
CaMKK-associated AMPK signaling in rat L6 cells; the accessed abstract does not resolve CAMKK1 versus CAMKK2.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
Where it participates (unsigned role)
Adding (S)-6-gingerol increased AMPK alpha Thr172 phosphorylation in rat L6 cells, with CaMKK-associated signaling.
Experimental context and source evidence
- dose
- (S)-6-Gingerol; dose-response, exact range not in accessed abstract
- duration
- Time-dependent response; exact times not in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Rat L6 skeletal muscle myotubes
- limitations
- Calcium/CaMKK-associated signaling does not demonstrate dietary calcium depletion or calcium-supplement synergy; no human glycemic outcome was tested. The accessed abstract does not identify a CaMKK isoform or establish genetic necessity.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Rat L6 skeletal muscle myotubes
- plain_language
- Adding (S)-6-gingerol increased AMPK alpha Thr172 phosphorylation in rat L6 cells, with CaMKK-associated signaling.
- primary_references
- (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i. (2013). https://pubmed.ncbi.nlm.nih.gov/23958199/ DOI: 10.18433/j34g7p
- route
- In vitro addition
- tissue
- Skeletal muscle cell model
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 162–171
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Rat L6 skeletal muscle myotubes · source_derived_draft · unverified_draft
## gingerols-6-l6-ampk Adding (S)-6-gingerol increased AMPK alpha Thr172 phosphorylation in rat L6 cells, with CaMKK-associated signaling. Model/species: Rat L6 skeletal muscle myotubes Tissue: Skeletal muscle cell model Exposure: (S)-6-Gingerol; dose-response, exact range not in accessed abstract Route: In vitro addition Duration: Time-dependent response; exact times not in accessed abstract Limits: Calcium/CaMKK-associated signaling does not demonstrate dietary calcium depletion or calcium-supplement synergy; no human glycemic outcome was tested. The accessed abstract does not identify a CaMKK isoform or establish genetic necessity. Primary reference: (S)-[6]-Gingerol enhances glucose uptake in L6 myotubes by activation of AMPK in response to [Ca2+]i. (2013). https://pubmed.ncbi.nlm.nih.gov/23958199/ DOI: 10.18433/j34g7p Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.