Component

Quinic acid

Quinic acid. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The Caco-2 experiments also supported active efflux of quinic acid.

    Quinic acid → Caco-2 efflux of quinic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/33336676.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713", "start_char": 0, "end_char": 1430, "text_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713"}
    experimental_model
    Bidirectional Caco-2 permeability assay
    exposure
    Chlorogenic acid and quinic acid; dosing details not provided in indexed abstract
    limitations
    Active efflux is demonstrated at the assay level. A specific ABC transporter, gene knockout result or clinical drug interaction is not established by the abstract.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human cell line
    plain_language
    A breakdown product has its own transport behavior.
    primary_references
    [chlorogenic_acid-p33336676] Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay. (2021). https://pubmed.ncbi.nlm.nih.gov/33336676/ DOI: 10.1039/d0fo02629h
    tissue_or_cell_type
    Cultured intestinal epithelial barrier

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 230–241

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Bidirectional Caco-2 permeability assay · source_derived_draft · unverified_draft

    ### chlorogenic_acid-quinic-efflux The Caco-2 experiments also supported active efflux of quinic acid. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A breakdown product has its own transport behavior. organism: Human cell line tissue_or_cell_type: Cultured intestinal epithelial barrier experimental_model: Bidirectional Caco-2 permeability assay limitations: Active efflux is demonstrated at the assay level. A specific ABC transporter, gene knockout result or clinical drug interaction is not established by the abstract. exposure: Chlorogenic acid and quinic acid; dosing details not provided in indexed abstract evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/33336676.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713", "start_char": 0, "end_char": 1430, "text_sha256": "3d5e4e2401998597110958f37fba3e510241ede894a037b6d0701be1689ea713"} [chlorogenic_acid-p33336676] Demonstrating the involvement of an active efflux mechanism in the intestinal absorption of chlorogenic acid and quinic acid using a Caco-2 bidirectional permeability assay. (2021). https://pubmed.ncbi.nlm.nih.gov/33336676/ DOI: 10.1039/d0fo02629h
    Complete structured claim and evidence

What acts on it

  1. Quinic acid supplies the other component of the chlorogenic-acid ester.

    Chlorogenic acid / 5-O-caffeoylquinic acid → Quinic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/11208940.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8", "start_char": 0, "end_char": 1299, "text_sha256": "651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8"}
    experimental_model
    Randomized-order crossover in seven ileostomy volunteers
    exposure
    2.8 mmol chlorogenic acid or caffeic acid on separate days; 24-hour collections
    limitations
    Disappearance from ileal effluent is not intact-parent systemic bioavailability. Participants lacked normal colonic processing; no therapeutic outcome was tested.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human
    plain_language
    Breaking the ester creates different molecules with their own handling.
    primary_references
    [chlorogenic_acid-p11208940] Chlorogenic acid and caffeic acid are absorbed in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11208940/ DOI: 10.1093/jn/131.1.66
    tissue_or_cell_type
    Small intestine; ileal effluent and urine

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 126–137

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order crossover in seven ileostomy volunteers · source_derived_draft · unverified_draft

    ### chlorogenic_acid-quinic-ester Quinic acid supplies the other component of the chlorogenic-acid ester. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Breaking the ester creates different molecules with their own handling. organism: Human tissue_or_cell_type: Small intestine; ileal effluent and urine experimental_model: Randomized-order crossover in seven ileostomy volunteers limitations: Disappearance from ileal effluent is not intact-parent systemic bioavailability. Participants lacked normal colonic processing; no therapeutic outcome was tested. exposure: 2.8 mmol chlorogenic acid or caffeic acid on separate days; 24-hour collections evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/11208940.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8", "start_char": 0, "end_char": 1299, "text_sha256": "651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8"} [chlorogenic_acid-p11208940] Chlorogenic acid and caffeic acid are absorbed in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11208940/ DOI: 10.1093/jn/131.1.66
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Chlorogenic-acid hydrolysis was detected in selected E. coli, B. lactis and L. gasseri isolates; activity was mainly intracellular.

    Gut-isolate cinnamoyl esterase activities, genes unresolved → Chlorogenic acid / 5-O-caffeoylquinic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/11412317.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2c6244869c8a620b69559006cf5bd4a71d44839b0920a8b388eb933be1cfa9a6", "start_char": 0, "end_char": 1812, "text_sha256": "2c6244869c8a620b69559006cf5bd4a71d44839b0920a8b388eb933be1cfa9a6"}
    experimental_model
    Culture and enzymatic characterization of human fecal isolates
    exposure
    Thirty-five isolates screened; six esterase-positive isolates identified
    limitations
    Activity was strain-specific and genes were not identified. The study does not establish that all members of a named species or commercial probiotics have this activity.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human-derived bacterial isolates
    plain_language
    Some gut bacteria can open the ester, changing the compounds available to the host.
    primary_references
    [chlorogenic_acid-p11412317] Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. (2001). https://pubmed.ncbi.nlm.nih.gov/11412317/ DOI: 10.1046/j.1365-2672.2001.01316.x
    tissue_or_cell_type
    Anaerobic cultures; intracellular esterase activity

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 204–215

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Culture and enzymatic characterization of human fecal isolates · source_derived_draft · unverified_draft

    ### chlorogenic_acid-bacterial-hydrolysis Chlorogenic-acid hydrolysis was detected in selected E. coli, B. lactis and L. gasseri isolates; activity was mainly intracellular. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Some gut bacteria can open the ester, changing the compounds available to the host. organism: Human-derived bacterial isolates tissue_or_cell_type: Anaerobic cultures; intracellular esterase activity experimental_model: Culture and enzymatic characterization of human fecal isolates limitations: Activity was strain-specific and genes were not identified. The study does not establish that all members of a named species or commercial probiotics have this activity. exposure: Thirty-five isolates screened; six esterase-positive isolates identified evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/11412317.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "2c6244869c8a620b69559006cf5bd4a71d44839b0920a8b388eb933be1cfa9a6", "start_char": 0, "end_char": 1812, "text_sha256": "2c6244869c8a620b69559006cf5bd4a71d44839b0920a8b388eb933be1cfa9a6"} [chlorogenic_acid-p11412317] Isolation and characterization of human colonic bacteria able to hydrolyse chlorogenic acid. (2001). https://pubmed.ncbi.nlm.nih.gov/11412317/ DOI: 10.1046/j.1365-2672.2001.01316.x
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards