Component

Takifugu obscurus Slc4a11A

Takifugu obscurus Slc4a11A. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Seawater acclimation increased renal apical Slc4a11A expression and accompanied urine boric-acid concentrations of 19 mM versus 0.020 mM in freshwater fish.

    Takifugu obscurus Slc4a11A → Urinary boron excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/36435196.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c", "start_char": 0, "end_char": 1651, "text_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c"}
    experimental_model
    Freshwater/seawater acclimation and Xenopus oocyte transporter expression
    exposure
    Freshwater versus seawater; boric-acid exposure during voltage clamp
    limitations
    Fish paralog is distinct from human SLC4A11. Borate uniport, boric-acid/OH cotransport and boric-acid/H exchange were not distinguished.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Takifugu obscurus pufferfish; Xenopus expression host
    plain_language
    The fish kidney adjusts to the much greater boron exposure from seawater.
    primary_references
    [boron-p36435196] Seawater fish use an electrogenic boric acid transporter, Slc4a11A, for boric acid excretion by the kidney. (2023). https://pubmed.ncbi.nlm.nih.gov/36435196/ DOI: 10.1016/j.jbc.2022.102740
    tissue_or_cell_type
    Kidney tubular apical membrane and heterologous membrane

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 261–272

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Freshwater/seawater acclimation and Xenopus oocyte transporter expression · source_derived_draft · unverified_draft

    ### boron-pufferfish-renal-adaptation Seawater acclimation increased renal apical Slc4a11A expression and accompanied urine boric-acid concentrations of 19 mM versus 0.020 mM in freshwater fish. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: The fish kidney adjusts to the much greater boron exposure from seawater. organism: Takifugu obscurus pufferfish; Xenopus expression host tissue_or_cell_type: Kidney tubular apical membrane and heterologous membrane experimental_model: Freshwater/seawater acclimation and Xenopus oocyte transporter expression limitations: Fish paralog is distinct from human SLC4A11. Borate uniport, boric-acid/OH cotransport and boric-acid/H exchange were not distinguished. exposure: Freshwater versus seawater; boric-acid exposure during voltage clamp evidence_span: {"source_cache": "artifacts/boron-research/36435196.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c", "start_char": 0, "end_char": 1651, "text_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c"} [boron-p36435196] Seawater fish use an electrogenic boric acid transporter, Slc4a11A, for boric acid excretion by the kidney. (2023). https://pubmed.ncbi.nlm.nih.gov/36435196/ DOI: 10.1016/j.jbc.2022.102740
    Complete structured claim and evidence

  2. Pufferfish Slc4a11A expression increased boron accumulation, intracellular pH and outward currents during boric-acid exposure in oocytes, independently of extracellular sodium.

    Takifugu obscurus Slc4a11A → Cellular boric-acid-equivalent transport source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/boron-research/36435196.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c", "start_char": 0, "end_char": 1651, "text_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c"}
    experimental_model
    Freshwater/seawater acclimation and Xenopus oocyte transporter expression
    exposure
    Freshwater versus seawater; boric-acid exposure during voltage clamp
    limitations
    Fish paralog is distinct from human SLC4A11. Borate uniport, boric-acid/OH cotransport and boric-acid/H exchange were not distinguished.
    nutrient_topic
    Boron research collection; topical membership is not evidence of a direct dietary effect. · Boron
    organism
    Takifugu obscurus pufferfish; Xenopus expression host
    plain_language
    A fish version really did transport boric-acid equivalents in this experiment; that does not validate the disputed human assignment.
    primary_references
    [boron-p36435196] Seawater fish use an electrogenic boric acid transporter, Slc4a11A, for boric acid excretion by the kidney. (2023). https://pubmed.ncbi.nlm.nih.gov/36435196/ DOI: 10.1016/j.jbc.2022.102740
    tissue_or_cell_type
    Kidney tubular apical membrane and heterologous membrane

    Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17) · lines 248–259

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Freshwater/seawater acclimation and Xenopus oocyte transporter expression · source_derived_draft · unverified_draft

    ### boron-pufferfish-transporter Pufferfish Slc4a11A expression increased boron accumulation, intracellular pH and outward currents during boric-acid exposure in oocytes, independently of extracellular sodium. Condition category: normal nutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect. plain_language: A fish version really did transport boric-acid equivalents in this experiment; that does not validate the disputed human assignment. organism: Takifugu obscurus pufferfish; Xenopus expression host tissue_or_cell_type: Kidney tubular apical membrane and heterologous membrane experimental_model: Freshwater/seawater acclimation and Xenopus oocyte transporter expression limitations: Fish paralog is distinct from human SLC4A11. Borate uniport, boric-acid/OH cotransport and boric-acid/H exchange were not distinguished. exposure: Freshwater versus seawater; boric-acid exposure during voltage clamp evidence_span: {"source_cache": "artifacts/boron-research/36435196.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c", "start_char": 0, "end_char": 1651, "text_sha256": "f33e845c95cab0ebe899c99562ebb23f43292cbab645601a5ab51a421fdc5f8c"} [boron-p36435196] Seawater fish use an electrogenic boric acid transporter, Slc4a11A, for boric acid excretion by the kidney. (2023). https://pubmed.ncbi.nlm.nih.gov/36435196/ DOI: 10.1016/j.jbc.2022.102740
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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