Component

Proliferation of cultured human prostate carcinoma cells

Proliferation of cultured human prostate carcinoma cells. Species, exposure and limitations are retained in each linked claim.

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The alpha-tocopherol combination effect was not reproduced with beta-tocopherol, ascorbic acid or probucol.

    Lycopene → Proliferation of cultured human prostate carcinoma cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/9784387.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15", "start_char": 0, "end_char": 701, "text_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15"}
    experimental_model
    Combined-compound proliferation assay
    exposure
    Lycopene below 1 micromolar and alpha-tocopherol 50 micromolar
    limitations
    Reported in-vitro synergy; not proof of cancer prevention or a safe/effective supplement combination.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human DU-145 and PC-3 prostate carcinoma cells
    plain_language
    The result cannot be generalized to every antioxidant partner.
    primary_references
    [lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351
    tissue_or_cell_type
    Cultured cell proliferation

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 884–895

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Combined-compound proliferation assay · source_derived_draft · unverified_draft

    ### lycopene-combination-specificity The alpha-tocopherol combination effect was not reproduced with beta-tocopherol, ascorbic acid or probucol. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: The result cannot be generalized to every antioxidant partner. organism: Human DU-145 and PC-3 prostate carcinoma cells tissue_or_cell_type: Cultured cell proliferation experimental_model: Combined-compound proliferation assay limitations: Reported in-vitro synergy; not proof of cancer prevention or a safe/effective supplement combination. exposure: Lycopene below 1 micromolar and alpha-tocopherol 50 micromolar evidence_span: {"source_cache": "artifacts/lycopene-research/9784387.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15", "start_char": 0, "end_char": 701, "text_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15"} [lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351
    Complete structured claim and evidence

  2. Combined lycopene and alpha-tocopherol inhibited proliferation by up to about 90%; lycopene alone was weak in these cultures.

    Alpha-tocopherol → Proliferation of cultured human prostate carcinoma cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/9784387.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15", "start_char": 0, "end_char": 701, "text_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15"}
    experimental_model
    Combined-compound proliferation assay
    exposure
    Lycopene below 1 micromolar and alpha-tocopherol 50 micromolar
    limitations
    Reported in-vitro synergy; not proof of cancer prevention or a safe/effective supplement combination.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human DU-145 and PC-3 prostate carcinoma cells
    plain_language
    A vitamin E interaction was observed, but only in the tested cancer-cell systems.
    primary_references
    [lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351
    tissue_or_cell_type
    Cultured cell proliferation

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 871–882

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Combined-compound proliferation assay · source_derived_draft · unverified_draft

    ### lycopene-vitamin-e-combination Combined lycopene and alpha-tocopherol inhibited proliferation by up to about 90%; lycopene alone was weak in these cultures. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: A vitamin E interaction was observed, but only in the tested cancer-cell systems. organism: Human DU-145 and PC-3 prostate carcinoma cells tissue_or_cell_type: Cultured cell proliferation experimental_model: Combined-compound proliferation assay limitations: Reported in-vitro synergy; not proof of cancer prevention or a safe/effective supplement combination. exposure: Lycopene below 1 micromolar and alpha-tocopherol 50 micromolar evidence_span: {"source_cache": "artifacts/lycopene-research/9784387.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15", "start_char": 0, "end_char": 701, "text_sha256": "51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15"} [lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards