{"id":"23a5bdfc-4ff1-5444-86eb-a265970f2109","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-combination-specificity","predicate":"showed_partner_specific_effect_on","statement":"The alpha-tocopherol combination effect was not reproduced with beta-tocopherol, ascorbic acid or probucol.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e70daeb9-b5fc-5a55-82e0-fa5f86fb72df","mechanism_event_label":"The result cannot be generalized to every antioxidant partner.","subject":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"object":{"id":"d149b03c-68ea-5975-8ead-11dd397f2d62","slug":"prostate-cell-proliferation","display_name":"Proliferation of cultured human prostate carcinoma cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e70daeb9-b5fc-5a55-82e0-fa5f86fb72df","stable_key":"aad5a443-96e9-52eb-963a-812e90f9f896:lycopene-combination-specificity-event","event_type":"biochemical_relationship","label":"The result cannot be generalized to every antioxidant partner.","description":"The alpha-tocopherol combination effect was not reproduced with beta-tocopherol, ascorbic acid or probucol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"40a6525a-76b8-576e-b73d-1e11aecf5f8d","slug":"alpha-tocopherol","display_name":"Alpha-tocopherol","entity_type_key":"small_molecule"},"role":"effective_partner","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0b16e027-7a68-55ae-8e33-eae8b5cd1e9e","slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d149b03c-68ea-5975-8ead-11dd397f2d62","slug":"prostate-cell-proliferation","display_name":"Proliferation of cultured human prostate carcinoma cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/lycopene-research/9784387.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15\", \"start_char\": 0, \"end_char\": 701, \"text_sha256\": \"51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Combined-compound proliferation assay","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Lycopene below 1 micromolar and alpha-tocopherol 50 micromolar","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reported in-vitro synergy; not proof of cancer prevention or a safe/effective supplement combination.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lycopene research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lycopene","display_name":"Lycopene","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human DU-145 and PC-3 prostate carcinoma cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The result cannot be generalized to every antioxidant partner.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cultured cell proliferation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"80a29120-5326-5734-9bc3-4d47475588a9","evidence_kind":"source_excerpt","locator":"Lines 884-895","start_line":884,"end_line":895,"excerpt":"### lycopene-combination-specificity\nThe alpha-tocopherol combination effect was not reproduced with beta-tocopherol, ascorbic acid or probucol.\nCondition category: normal\nnutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The result cannot be generalized to every antioxidant partner.\norganism: Human DU-145 and PC-3 prostate carcinoma cells\ntissue_or_cell_type: Cultured cell proliferation\nexperimental_model: Combined-compound proliferation assay\nlimitations: Reported in-vitro synergy; not proof of cancer prevention or a safe/effective supplement combination.\nexposure: Lycopene below 1 micromolar and alpha-tocopherol 50 micromolar\nevidence_span: {\"source_cache\": \"artifacts/lycopene-research/9784387.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15\", \"start_char\": 0, \"end_char\": 701, \"text_sha256\": \"51bb94173c1f98ab622ff028dfefaa016eb3fb5021f40f79e1d7d02bceaa7c15\"}\n[lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351","model_system":"Combined-compound proliferation assay","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [lycopene-p9784387] Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. (1998). https://pubmed.ncbi.nlm.nih.gov/9784387/ DOI: 10.1006/bbrc.1998.9351","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d1e09874-8bde-548f-9664-26ad5eedb3c7","stable_key":"import-aad5a443-96e9-52eb-963a-812e90f9f896","title":"Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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