Component

Prazosin

2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Prazosin antagonized modafinil improvement in planning accuracy in a 12-man crossover trial.

    Prazosin → Human planning-task accuracy Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
    experimental_condition
    Modafinil condition alpha1-antagonist exposure · Prazosin Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Modafinil condition joint exposure · Modafinil Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Prazosin plus modafinil", "comparator": "Modafinil condition", "endpoint": "Prazosin antagonized modafinil improvement in planning accuracy in a 12-man crossover trial.", "effect_direction": "decrease", "combination": "joint", "conditions": [{"entity_slug": "prazosin", "state": "alpha1-antagonist exposure"}, {"entity_slug": "modafinil", "state": "joint exposure"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    Prazosin antagonized modafinil improvement in planning accuracy in a 12-man crossover trial.
    primary_references
    Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. | 2010 | DOI 10.1177/0269881109105899 | PMID 19493958 | https://pubmed.ncbi.nlm.nih.gov/19493958/
    source_locator
    Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.

    Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 89–89

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion. · Recorded from source · Recorded from source

    There is also **human experimental evidence**, omitted from the supplied account. In a 12-man crossover trial, prazosin antagonized modafinil's improvement in planning accuracy. The combined drugs nevertheless increased completion time and potentiated some physiological responses. Accuracy, speed and autonomic effects therefore cannot be represented by one shared sign. This supports an α1-associated contribution to selected cognitive effects, not direct binding of modafinil to α1 receptors. [Prazosin/modafinil trial](https://pubmed.ncbi.nlm.nih.gov/19493958/)
    Complete structured claim and evidence

  2. Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.

    Prazosin → Human task completion time Recorded from sourceungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
    experimental_condition
    Modafinil condition alpha1-antagonist exposure · Prazosin Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_condition
    Modafinil condition joint exposure · Modafinil Condition belongs to the full experimental contrast; do not separate a joint intervention.
    experimental_contrast
    {"intervention": "Prazosin plus modafinil", "comparator": "Modafinil condition", "endpoint": "Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.", "effect_direction": "increase", "combination": "joint", "conditions": [{"entity_slug": "prazosin", "state": "alpha1-antagonist exposure"}, {"entity_slug": "modafinil", "state": "joint exposure"}]} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
    plain_language
    Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.
    primary_references
    Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. | 2010 | DOI 10.1177/0269881109105899 | PMID 19493958 | https://pubmed.ncbi.nlm.nih.gov/19493958/
    source_locator
    Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.

    Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 89–89

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion. · Recorded from source · Recorded from source

    There is also **human experimental evidence**, omitted from the supplied account. In a 12-man crossover trial, prazosin antagonized modafinil's improvement in planning accuracy. The combined drugs nevertheless increased completion time and potentiated some physiological responses. Accuracy, speed and autonomic effects therefore cannot be represented by one shared sign. This supports an α1-associated contribution to selected cognitive effects, not direct binding of modafinil to α1 receptors. [Prazosin/modafinil trial](https://pubmed.ncbi.nlm.nih.gov/19493958/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.