{"id":"2ebb09a7-253e-5c1a-985f-5fe111d78b6b","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:prazosin-time","predicate":"increases_in_recorded_experiment","statement":"Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0feb16d4-e2b2-5c9a-8817-824a4631016e","mechanism_event_label":"Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.","subject":{"id":"1f1102d5-b051-5410-8530-db8f034fe1eb","slug":"prazosin","display_name":"Prazosin","entity_type_key":"drug"},"object":{"id":"bff84910-82cb-5eee-9810-0f412b7d0afc","slug":"human-task-completion-time","display_name":"Human task completion time","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0feb16d4-e2b2-5c9a-8817-824a4631016e","stable_key":"6660bba2-4fa0-590a-bf52-9803a24bea9f:prazosin-time-event","event_type":"experimental_observation","label":"Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.","description":"There is also **human experimental evidence**, omitted from the supplied account. In a 12-man crossover trial, prazosin antagonized modafinil's improvement in planning accuracy. The combined drugs nevertheless increased completion time and potentiated some physiological responses. Accuracy, speed and autonomic effects therefore cannot be represented by one shared sign. This supports an α1-associated contribution to selected cognitive effects, not direct binding of modafinil to α1 receptors. [Prazosin/modafinil trial](https://pubmed.ncbi.nlm.nih.gov/19493958/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f1102d5-b051-5410-8530-db8f034fe1eb","slug":"prazosin","display_name":"Prazosin","entity_type_key":"drug"},"role":"tested factor","stoichiometry":null,"state_label":"Prazosin plus modafinil","sequence_order":0,"notes":""},{"entity":{"id":"bff84910-82cb-5eee-9810-0f412b7d0afc","slug":"human-task-completion-time","display_name":"Human task completion time","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""},{"entity":{"id":"624e6a4b-f96d-5d12-8206-30d1e1715c26","slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"},"role":"coadministered drug","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract checked; full methods and figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_condition","value_text":"joint exposure","comparator":"Modafinil condition","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"modafinil","display_name":"Modafinil","entity_type_key":"drug"}},{"dimension":"experimental_condition","value_text":"alpha1-antagonist exposure","comparator":"Modafinil condition","unit":null,"notes":"Condition belongs to the full experimental contrast; do not separate a joint intervention.","entity":{"slug":"prazosin","display_name":"Prazosin","entity_type_key":"drug"}},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Prazosin plus modafinil\", \"comparator\": \"Modafinil condition\", \"endpoint\": \"Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.\", \"effect_direction\": \"increase\", \"combination\": \"joint\", \"conditions\": [{\"entity_slug\": \"prazosin\", \"state\": \"alpha1-antagonist exposure\"}, {\"entity_slug\": \"modafinil\", \"state\": \"joint exposure\"}]}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. | 2010 | DOI 10.1177/0269881109105899 | PMID 19493958 | https://pubmed.ncbi.nlm.nih.gov/19493958/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5e1bb23d-8482-52f7-beee-0ef03ae6a40a","evidence_kind":"source_excerpt","locator":"Lines 89-89","start_line":89,"end_line":89,"excerpt":"There is also **human experimental evidence**, omitted from the supplied account. In a 12-man crossover trial, prazosin antagonized modafinil's improvement in planning accuracy. The combined drugs nevertheless increased completion time and potentiated some physiological responses. Accuracy, speed and autonomic effects therefore cannot be represented by one shared sign. This supports an α1-associated contribution to selected cognitive effects, not direct binding of modafinil to α1 receptors. [Prazosin/modafinil trial](https://pubmed.ncbi.nlm.nih.gov/19493958/)","model_system":"Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"17a64928-eaa2-5117-ba4f-52dcbdf9cc9e","stable_key":"import-6660bba2-4fa0-590a-bf52-9803a24bea9f","title":"Modafinil: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"006008cb4cfd183dd3b0846d3abc66c8ebf40cf1b6bd1f0bcdb4f4d937a8e115","revision_id":"c85b3e2e-c18a-59fc-9e79-5c375e64d119","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}