Component
Human task completion time
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract checked; full methods and figures not comprehensively reviewed.
- experimental_condition
- Modafinil condition alpha1-antagonist exposure · Prazosin Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_condition
- Modafinil condition joint exposure · Modafinil Condition belongs to the full experimental contrast; do not separate a joint intervention.
- experimental_contrast
- {"intervention": "Prazosin plus modafinil", "comparator": "Modafinil condition", "endpoint": "Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.", "effect_direction": "increase", "combination": "joint", "conditions": [{"entity_slug": "prazosin", "state": "alpha1-antagonist exposure"}, {"entity_slug": "modafinil", "state": "joint exposure"}]} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.
- plain_language
- Combined prazosin and modafinil increased planning-task completion time in the human crossover trial.
- primary_references
- Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteers. | 2010 | DOI 10.1177/0269881109105899 | PMID 19493958 | https://pubmed.ncbi.nlm.nih.gov/19493958/
- source_locator
- Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.
Modafinil: detailed mechanisms of action (reviewed 3 October 2026) · lines 89–89
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Twelve-man crossover trial; drug combination, selected task endpoints; no direct modafinil alpha1-binding conclusion. · Recorded from source · Recorded from source
There is also **human experimental evidence**, omitted from the supplied account. In a 12-man crossover trial, prazosin antagonized modafinil's improvement in planning accuracy. The combined drugs nevertheless increased completion time and potentiated some physiological responses. Accuracy, speed and autonomic effects therefore cannot be represented by one shared sign. This supports an α1-associated contribution to selected cognitive effects, not direct binding of modafinil to α1 receptors. [Prazosin/modafinil trial](https://pubmed.ncbi.nlm.nih.gov/19493958/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.